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Preparation method of traditional Chinese medicine composition for removing impurities by using ceramic membrane

A ceramic membrane and composition technology, which is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Affect the follow-up treatment of the extract, and achieve the effect of shortening the drying time, reducing thermal decomposition, and facilitating the molding of the preparation

Active Publication Date: 2021-07-02
JINLING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All these components not only have no biological activity or desired therapeutic effect, but also can affect the subsequent processing of the extract, such as drying efficiency
The resulting extract contains too much polysaccharide, which makes the extract too viscous, which affects the later formulation of the preparation. For example, in the process of granulation, due to the high proportion of the extract, the granules are not easy to form, which affects the yield of the granules
The existence of the above-mentioned components will also affect the clarity of the solution of the finished preparation, affect the compliance of patients taking medicine, etc.

Method used

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  • Preparation method of traditional Chinese medicine composition for removing impurities by using ceramic membrane
  • Preparation method of traditional Chinese medicine composition for removing impurities by using ceramic membrane
  • Preparation method of traditional Chinese medicine composition for removing impurities by using ceramic membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prepare the alcohol extract according to the following extraction process:

[0031] Weigh 414g of cicada slough, 230g of scutellaria baicalensis, 276g of earthworm, 230g of silkworm, 230g of Nepeta, 276g of aster, 414g of baicalensis, and 230g of myrobalan; In the extraction tank, add 14720mL 70% ethanol to reflux for extraction, extract 3 times, extract for 2 hours each time, filter through a 100-300 mesh screen, and combine the filtrates to obtain the alcohol extract.

[0032] Take the ethanol extract, select 0.2μm ceramic membrane, 0.1μm ceramic membrane, 0.02μm ceramic membrane to filter respectively. The experimental parameters are liquid medicine temperature 50°C-55°C, operating pressure 0.075MPa. The extract was filtered through the ceramic membrane and then circulated. After the medicinal liquid was balanced, the filtrate was collected, and each 2L of filtrate was regarded as a unit, and the time was recorded and sampled. When the liquid medicine is almost fin...

Embodiment 2

[0051] Prepare the water extract according to the following extraction process:

[0052] Weigh 414g of cicada slough, 230g of Scutellaria baicalensis, 276g of earthworm, 230g of silkworm, 230g of nepeta, 276g of aster, 414g of baicalensis, 230g of myrobalan;

[0053] Add 10 times the amount of water to Schizonepeta, soak for 2 hours, heat to boil and keep warm for 3 hours, collect the volatile oil of Schizonepeta, measure and record it; the dregs and residual liquid are set aside;

[0054] Add the cicada slough, scutellaria baicalensis, earthworm, aster, baebu, and myrobalan into the extraction tank in turn, add 14720mL of 70% ethanol to reflux extraction, extract 3 times, extract for 2 hours each time, filter through a 100-300 mesh screen, The filtrates are combined; alcohol extraction residues, nepeta medicinal residues, residual liquid, and silkworm are combined, decocted with water for 3 times, each time for 2.5 hours, the extract is filtered through a 100-300 mesh screen,...

Embodiment 3

[0060] Step (1), get raw medicinal materials according to the formula: cicada slough 414g, scutellaria baicalensis 230g, earthworm 276g, silkworm 230g, Nepeta 230g, aster 276g, basilica 414g, chebula 230g;

[0061] Step (2), add 10 times the amount of water to Schizonepeta, soak for 2 hours, heat to boiling and keep warm for 3 hours, collect the volatile oil of Schizonepeta, measure and record; the dregs and residual liquid are set aside; take the volatile oil of Schizonepeta, add 4 times Measure β-cyclodextrin, 4 times the amount of absolute ethanol, grind with a colloid mill for 10 minutes for inclusion, filter with suction, dry (temperature 50°C), pass through a 80-mesh sieve, and set aside;

[0062] Step (3), add the formula amount of cicada slough, scutellaria baicalensis, earthworm, aster, babe, and myrobalan into the extraction tank in sequence, add 14720mL of 70% ethanol for reflux extraction, and extract 3 times, each time for 2 hours, 100-300 mesh Filtrate through a ...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine composition for removing impurities by using a ceramic membrane. The preparation method comprises the following steps: adding water into herba schizonepetae, soaking the herba schizonepetae, heating the herba schizonepetae until the herba schizonepetae is boiled, carrying out heat preservation, collecting volatile oil, preparing an inclusion compound from the volatile oil, and and subjecting dregs and residual liquid to standing for later use; adding 60-80% ethanol into cicada slough, radix scutellariae, earthworm, radix asteris, radix stemonae and fructus chebulae, performing reflux extraction and filtering, performing ultrafiltration on an alcohol extract by adopting the ceramic membrane, and concentrating a filtrate; combining alcohol extraction dregs with fineleaf schizonepeta herb dregs, residual liquid and stiff silkworms, adding water for decoction, carrying out filtering, performing microfiltration on water extract by using the ceramic membrane, and concentrating a filtrate under reduced pressure; mixing the alcohol extract and the water extract to obtain a thick extract, adding dextrin, performing vacuum drying, crushing the dry extract, supplementing the dextrin, adding a proper amount of an adhesive, namely an ethanol solution, performing granulation, and performing drying; and adding the clathrate compound into the particles, and conducting uniform mixing. According to the invention, the index component baicalin with curative effect is enriched, and the extract yield of the extract can be obviously reduced. Meanwhile, the viscosity of the extract is improved, a preparation is easy to form, and a dissolving solution of the preparation is clear and transparent.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines and relates to extraction and purification techniques of traditional Chinese medicines, in particular to a preparation method of a traditional Chinese medicine composition using ceramic membranes to remove impurities. Background technique [0002] The traditional Chinese medicine composition is formed according to the principles of traditional Chinese medicine prescriptions, selecting appropriate medicines, determining the dosage, determining the appropriate dosage form and usage, and properly combining them. [0003] The preparation process of traditional Chinese medicine composition is an important link in the preparation of Chinese patent medicine, including two parts: extraction, purification process and preparation process. After determining the composition of traditional Chinese medicine, it is first necessary to conduct research on the preparation process combined with quality. ...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/16A61K47/69A61K35/62A61K35/64
CPCA61K35/64A61K36/539A61K35/62A61K36/28A61K36/904A61K36/185A61K36/538A61K9/1652A61K47/6951A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2300/00
Inventor 周红燕许润谢俊黄春玉张庆晓李剑徐向阳
Owner JINLING PHARMA
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