A kind of preparation method of medical dressing with drug-loading function

A functional and drug-loading technology, which is applied in the fields of pharmaceutical formulation, drug delivery, and medical science, can solve the problems that the hemostatic dressing cannot quickly and completely stop bleeding, has no obvious promotion effect on wound healing, and has poor barrier effect, so as to improve the drug loading capacity , promote wound healing, increase the effect of adhesion sites

Active Publication Date: 2022-05-27
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For acute wounds, the wound has a lot of bleeding, traditional hemostatic dressings cannot stop bleeding quickly and completely, and it is necessary to add hemostatic drugs to the dressing to achieve rapid hemostasis, or when treating chronic wounds, it is necessary to add antibacterial drugs to the dressing to treat inflammation , so medical dressings need to have a certain drug-loading performance
[0003] Traditional wound dressings, such as gauze, can protect the wound surface from mechanical damage and reduce bacterial invasion in the environment, and have good air permeability and moisture permeability, and can be used to treat superficial wounds, but the barrier of traditional dressings such as gauze The effect is poor, the possibility of bacterial invasion is high, and there is no obvious promotion effect on wound healing

Method used

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  • A kind of preparation method of medical dressing with drug-loading function
  • A kind of preparation method of medical dressing with drug-loading function
  • A kind of preparation method of medical dressing with drug-loading function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1) First dissolve 0.32g of cetyltrimethylammonium bromide (CTAB) in 280ml of deionized water, stir for 30 minutes, slowly drop 8ml of ammonia water, then heat in a water bath at 40°C and stir for 30 minutes. Finally, 2.44 ml of ethyl orthosilicate (TEOS) was added and stirred for 5 h. The turbid liquid was centrifuged in a centrifuge to obtain a white moist powder, which was washed three times with 75% ethanol solution. After centrifugation, it was placed in an oven at 70°C to dry. Finally, the white solid was mashed and calcined in a muffle furnace for 6 hours. After taking out the white powder, continue grinding to obtain mesoporous nano-silica (MSN).

[0043] 2) Mix 10% silk fibroin (SF) aqueous solution with 90% acetic acid in a mixing ratio of 10:90. An additional 2.0% chitosan (CS) was added. SF / CS microspheres were prepared.

[0044] 3) Mix 10% SF aqueous solution and 90% acetic acid solution in a ratio of 10:90, add 5% MSN (MSN / CS=5wt%), and sonicate for 2h...

Embodiment 2

[0046] 1) First dissolve 0.32g of cetyltrimethylammonium bromide (CTAB) in 280ml of deionized water, stir for 30 minutes, slowly drop 8ml of ammonia water, then heat in a water bath at 40°C and stir for 30 minutes. Finally, 2.44 ml of ethyl orthosilicate (TEOS) was added and stirred for 5 h. The cloudy liquid was centrifuged in a centrifuge to obtain a white moist powder, which was washed three times with 75% ethanol solution. After centrifugation, it was placed in an oven at 70°C to dry. Finally, the white solid was mashed and calcined in a muffle furnace for 6 hours. After taking out the white powder, continue grinding to obtain mesoporous nano-silica (MSN).

[0047] 2) Mix 10% silk fibroin (SF) aqueous solution with 90% acetic acid in a mixing ratio of 10:90, and then add 2% chitosan (CS). SF / CS microspheres were prepared.

[0048]3) Mix 10% SF aqueous solution and 90% acetic acid solution in a ratio of 10:90, add 10% MSN (MSN / CS=10wt%), and sonicate for 2h. Then 2.0% ...

Embodiment 3

[0050] 1) First, dissolve 0.32g of cetyltrimethylammonium bromide (CTAB) in 280ml of deionized water, stir for 30 minutes, slowly drop 8ml of ammonia water, then heat in a water bath at 40°C and stir for 30 minutes. Finally, 2.44 ml of ethyl orthosilicate (TEOS) was added and stirred for 5 h. The turbid liquid was centrifuged in a centrifuge to obtain a white moist powder, which was washed three times with 75% ethanol solution. After centrifugation, it was placed in an oven at 70°C to dry. Finally, the white solid was mashed and calcined in a muffle furnace for 6 hours. After taking out the white powder, continue grinding to obtain mesoporous nano-silica (MSN).

[0051] 3) Mix 10% silk fibroin (SF) aqueous solution with 90% acetic acid in a mixing ratio of 10:90, and then add 2% chitosan (CS). SF / CS microspheres were prepared.

[0052] 3) Mix 10% SF aqueous solution and 90% acetic acid solution in a ratio of 10:90, add 15% MSN (MSN / CS=15wt%), and sonicate for 2h. Then 2.0...

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Abstract

The invention discloses a medical dressing with a drug-carrying function and a preparation method thereof. The preparation method comprises the following steps: dropping ammonia water into a cetyltrimethylammonium bromide (CTAB) solution, heating and stirring in a water bath. Finally, add tetraethyl orthosilicate (TEOS) and stir at high speed. The turbid liquid was centrifuged in a centrifuge and washed three times with 75% ethanol solution. After centrifugation, dry. Finally, the white solid is mashed and calcined in a muffle furnace. Take out and grind to obtain mesoporous nano-silica (MSN). The silk fibroin (SF) aqueous solution was mixed with acetic acid, followed by the addition of chitosan (CS). SF / CS microspheres were prepared. SF aqueous solution and acetic acid solution were mixed in a certain proportion, MSN was added, and sonicated. Add chitosan and stir. MSN-SF / CS was prepared by electrostatic spraying method, and MSN-SF / CS microspheres were sprayed on the SF / PCL-PVA unidirectional water-conducting film. The formed functional medical dressing can solve the shortcomings of the single-layer nanofiber membrane for poor humidity control around the wound and the insufficient functionality of the unidirectional water-conducting nanofiber membrane, thereby promoting wound healing.

Description

technical field [0001] The invention belongs to the field of biomedical textiles, in particular to a preparation method of a medical dressing with a drug-carrying function. Background technique [0002] For acute wounds, there is a lot of bleeding on the wound surface. Traditional hemostatic dressings cannot stop bleeding quickly and completely. It is necessary to add hemostatic drugs to the dressings to achieve rapid hemostasis. Or when treating chronic wounds, it is necessary to add antibiotics to the dressings to treat inflammation. Therefore, medical dressings need to have certain drug-carrying properties. [0003] Traditional wound dressings such as gauze can protect the wound from mechanical damage and reduce bacterial invasion in the environment, and have good air permeability and moisture permeability, which can be used to treat superficial wounds, but the barrier of traditional dressings such as gauze is The effect is poor, the possibility of bacterial invasion is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/32A61L15/24A61L15/44A61L15/46C01B33/18D04H1/4382D04H1/728B82Y40/00
CPCA61L15/28A61L15/18A61L15/32A61L15/44A61L15/46A61L15/24C01B33/18B82Y40/00D04H1/4382D04H1/728A61L2400/12A61L2300/622A61L2300/252A61L2300/404C08L89/00C08L5/08C08L29/04
Inventor 李婷婷孙利钟言沁林佳弘楼静文
Owner TIANJIN POLYTECHNIC UNIV
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