Uric acid microwave biosensor based on RFID concept and application thereof

A biosensor, uric acid technology, applied in the field of biosensors, can solve the problems of complicated and cumbersome operation, low detection accuracy, etc., and achieve the effects of improving sensitivity and accuracy, saving detection time, and convenient and fast detection operation.

Active Publication Date: 2021-08-06
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the technical problem to be solved by the present invention is to overcome the defects of complex and cumbersome operation and low detection accuracy in the prior art

Method used

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  • Uric acid microwave biosensor based on RFID concept and application thereof
  • Uric acid microwave biosensor based on RFID concept and application thereof
  • Uric acid microwave biosensor based on RFID concept and application thereof

Examples

Experimental program
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Embodiment 1

[0029] A kind of uric acid microwave biosensor embodiment one based on the RFID concept provided by the present invention is introduced below, see Figure 1 to Figure 4 , embodiment one includes:

[0030] See Figure 1 to Figure 4 As shown, a uric acid microwave biosensor based on the RFID concept includes a first substrate 100, a second substrate 200, and a third substrate 300 that are sequentially stacked, the first substrate 100 is provided with a microfluidic channel, and the second substrate 200 is provided with a The metal capacitor structure 210 , the metal capacitor structure 210 is calibrated and bonded with the microfluidic channel, and the resonator module 310 is arranged on the third substrate 300 .

[0031] The specific design structure of each substrate is as follows:

[0032] Resonator module 310: the resonator module 310 includes a plurality of separation rings 311, the plurality of separation rings 311 are arranged on the third substrate 300 (preferably a PC...

Embodiment 2

[0048] The second embodiment of a uric acid microwave biosensor based on the RFID concept provided by the present invention will be introduced below. The second embodiment is realized based on the first embodiment above, and is expanded to a certain extent on the basis of the first embodiment.

[0049] The microwave biosensor in this embodiment is a detachable structure, and any biomarker-sensitive structure that meets the size of the resonator can be used multiple times. The specific design structure is as follows:

[0050] The microwave resonator proposed by the present invention is composed of a metal capacitor structure 210 and a resonator module 310 through electromagnetic coupling, wherein two wooden comb-shaped metal wires 211 and a dumbbell-shaped metal wire 212 are used in the capacitor area, and the resonator module 310 uses The two split rings 311 are connected by means of electromagnetic coupling. The gap in the capacitance area and the opening of the separation r...

Embodiment 3

[0055] The third application example of a uric acid microwave biosensor based on the RFID concept provided by the present invention is introduced below. The third example is implemented based on the first example above, and is expanded to a certain extent on the basis of the first example.

[0056] This embodiment provides the application of the uric acid microwave biosensor based on the RFID concept in detecting the concentration of uric acid. During the measurement, the uric acid solution to be tested is injected into the microfluidic channel. When the concentration of the uric acid solution changes, because the dielectric constant of different uric acid solutions is different, and the concentration is proportional to the dielectric constant, the uric acid solution of different concentrations passes through the microfluidic channel. After the input end of the fluid channel flows into the cavity of the microfluidic channel, it will fully contact the metal capacitor structure 2...

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Abstract

The invention relates to a uric acid microwave biosensor based on an RFID concept. The uric acid microwave biosensor comprises a first substrate, a second substrate and a third substrate which are sequentially stacked, the first substrate is provided with a microfluid channel, the microfluid channel comprises a cavity, and the cavity is used for containing quantitative to-be-detected solution; the second substrate is provided with a metal capacitor structure, and the metal capacitor structure and the cavity are calibrated and bonded; and the third substrate is provided with a resonator module, the resonator module comprises a plurality of separation rings, and the plurality of separation rings are mutually nested to form a complementary structure. The uric acid microwave biosensor has a high quality factor, a to-be-detected solution is fixed in the cavity, so that the detection position and the solution shape are fixed, the detection sensitivity and accuracy of the uric acid microwave biosensor are remarkably improved, and a feasible scheme of close-range non-contact / wireless measurement can be provided when measurement of biosensing response is realized; and the whole detection operation is convenient and rapid, the detection time is saved, and commercialized popularization and application are facilitated.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a uric acid microwave biosensor based on the concept of RF ID and its application. Background technique [0002] Uric acid is a metabolic product of the human body and the final product of purine metabolism. If the uric acid concentration in the human body is abnormal, it will affect the normal function of human cells, and it will also reflect the related diseases of purine metabolism. Long-term high uric acid will cause gout, hyperuricemia, uric acid nephropathy and other diseases, so uric acid detection is very important. Through the detection of uric acid concentration, it can accurately reflect the change of its own uric acid, grasp whether the concentration of uric acid exceeds the standard, and help the human body avoid various diseases caused by high or low uric acid. It plays an important role in the analysis of clinical diagnosis and treatment of diseases. increasin...

Claims

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Application Information

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IPC IPC(8): G01N22/00G01N27/22B01L3/00
CPCG01N22/00G01N27/22B01L3/5027
Inventor 强天高敏佳马杨川雷玉双
Owner JIANGNAN UNIV
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