Incorporating multiple targets in trajectory optimization for radiotherapy treatment planning

Abstract

Methods of treatment trajectory optimization for radiotherapy treatment of multiple targets include determining beam's eye view (BEV) regions and a BEV region connectivity manifold for each target group of a plurality of target groups separately. The information contained in the BEV regions and the BEV region connectivity manifolds for all target groups is used to guide an optimizer to find optimal treatment trajectories. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.

Description

Background technique [0001] A significant progress has been made in the reverse therapeutic plan of an outer lead radiation therapy using, for example, IMRT and VMAT treatment modes. As planned quality requirements, the role of automated and higher degree of personalized treatment programs in the treatment requirements and patient throughput in the clinic have become increasingly important. Select treatment fields such as VMAT trajectory or IMRT fields may be required prior to reverse optimization of the MLC blade sequence and dose rate in the radiological treatment plan. Treatment of geometry (eg, one or more equal central points, starter angles, and stop rack angle, as well as one or more collimator angles of VMAT arc, or stop position, rack angle, The choice of bed angle and collimator angle may be determined by the clinical scheme of a given treatment site. This solution may be a secondary place in consideration of the variability of the patient anatomical structure and clinic...

AI Technical Summary

Problems solved by technology

Given the variability in patient anatomy and clinical goals, this regimen may be suboptimal

Additionally, radiation therapy treatment may involve tumors or lesions that may have very different volumes

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