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Traditional Chinese medicine probiotic fermentation product, compound and composition and application of traditional Chinese medicine probiotic fermentation product, compound and composition in preparation of products with anti-helicobacter pylori effect

A technology of fermented products and probiotics, which is applied in the field of biomedicine to achieve the effects of low toxic and side effects, wide application prospects, and rich sources

Active Publication Date: 2021-09-17
深圳海创生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are few reports on the use of traditional Chinese medicine probiotic fermented products for anti-Helicobacter pylori; therefore, it has important application value to develop a traditional Chinese medicine probiotic fermented product with anti-Helicobacter pylori effect; especially the development of traditional Chinese medicine probiotic fermented products A small molecular compound with novel structure against Helicobacter pylori has more significance

Method used

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  • Traditional Chinese medicine probiotic fermentation product, compound and composition and application of traditional Chinese medicine probiotic fermentation product, compound and composition in preparation of products with anti-helicobacter pylori effect
  • Traditional Chinese medicine probiotic fermentation product, compound and composition and application of traditional Chinese medicine probiotic fermentation product, compound and composition in preparation of products with anti-helicobacter pylori effect
  • Traditional Chinese medicine probiotic fermentation product, compound and composition and application of traditional Chinese medicine probiotic fermentation product, compound and composition in preparation of products with anti-helicobacter pylori effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Due to the preparation of hawthorn-Lactobacillus rhamnosus fermented product, Adenophora-bifidobacterium fermented product and the compound shown in formula I

[0041] (1) Preparation of Hawthorn-Lactobacillus rhamnosus Ferment:

[0042] Fresh hawthorn was chopped and homogenized (50 g), and added to Lactobacillus rhamnosus fermentation medium (800 mL) containing yeast powder 5 g / L, peptone 10 g / L, and beef extract 15 g / L to ferment for 12 h. The fermentation product was collected, centrifuged for 10 minutes, the supernatant was collected, and lyophilized at low temperature to obtain a hawthorn-rhamnosus fermentation product.

[0043] (2) Preparation of Radix Ginseng-Bifidobacteria fermented product:

[0044] Chopped and homogenized (80g) of fresh sea ginseng, and added to bifidobacterium fermentation medium (1000mL) containing yeast powder 5g / L, peptone 10g / L, and beef extract 15g / L to ferment for 12h. Collect the fermentation product, centrifuge for 10 min...

experiment example

[0050] In order to evaluate the compound (abbreviated as LMRS-1), hawthorn-Lactobacillus rhamnosus fermented product (abbreviated as SZLM) and Adenophora-bifidobacterium fermented product (abbreviated as SZLM) prepared by the above method of the present invention SSBS), and Hawthorn-Lactobacillus rhamnosus fermentation product and Radix Ginseng-Bifidobacteria fermentation product are the mixture (abbreviated as SLSB) that the mass ratio is 1:1 to have anti-Helicobacter pylori proliferation effect, carry out following effect embodiment .

[0051] Inoculate Helicobacter pylori into the culture medium, add LMRS-1, SZLM, SSBS and SLSB respectively to make the final concentration 0.01mg / mL, 0.05mg / mL, 0.25mg / mL 37 ℃ constant temperature shaker (130r / min ) culture, samples were taken every 4 hours, and the absorbance value was measured in a microplate reader at a wavelength of 595 nm. The culture time was taken as the abscissa, and the corresponding absorbance value was taken as the...

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Abstract

The invention relates to the technical field of biomedicine, and particularly discloses a traditional Chinese medicine probiotic fermentation product, a compound and a composition and application of the traditional Chinese medicine probiotic fermentation product, the compound and the composition in preparation of products with an anti-helicobacter pylori effect. The traditional Chinese medicine probiotic fermentation product is a hawthorn-lactobacillus rhamnosus fermentation product, or an adenophora stricta-bifidobacterium fermentation product, or a composition consisting of the hawthorn-lactobacillus rhamnosus fermentation product and the adenophora stricta-bifidobacterium fermentation product. The compound has a structure shown in a formula I. The hawthorn-lactobacillus rhamnosus fermentation product, the adenophora stricta-bifidobacterium fermentation product and the compound with the structure shown in the formula I have anti-helicobacter pylori activity, so that the traditional Chinese medicine probiotic fermentation product, the compound and the composition can be used for preparing food, health-care products or medicines with the anti-helicobacter pylori effect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to traditional Chinese medicine probiotic fermented products, compounds and compositions and their application in preparing products with anti-helicobacter pylori effects. Background technique [0002] Helicobacter pylori is a Gram-negative microaerophilic bacterium that colonizes the gastric mucosa and can often cause gastritis, gastric ulcer and even gastric cancer. In recent years, the unique advantages of traditional Chinese medicine in the treatment of Helicobacter pylori-associated stomach disease and the eradication of Helicobacter pylori have attracted the attention of scholars. The use of traditional Chinese medicine in treatment or adjuvant therapy has become more and more frequent. Certain side effects, and due to the existence of plant cell walls, the amount of dissolution of traditional Chinese medicine in the body is less, so that the active ingredients entering th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K36/342A61K36/34A61K36/23A61K31/353A61K45/06A61P31/04A23L33/00C07D311/58
CPCA61K36/734A61K36/342A61K36/34A61K36/23A61K31/353A61K45/06A61P31/04A23L33/00C07D311/58A61K2236/19A23V2002/00A23V2400/175A23V2400/51A61K2300/00A23V2200/32
Inventor 刘志刚刘杰刘晓宇罗强罗敏罗丹王怀玲牛文芳龚苗
Owner 深圳海创生物科技有限公司
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