Application of glabridin in preparation of medicine for treating rheumatoid arthritis

Abstract

The invention provides application of glabridin in preparation of a medicine for treating rheumatoid arthritis. According to the application disclosed by the invention, action mechanism research finds that the glabridin GD can be used for remarkably inhibiting abnormal proliferation of rheumatoid arthritis synovioblasts (RA-FLS), the half inhibition ratio (IC50) of the glabridin GD is lower than 30 micrograms per milliliter, and the glabridin GD has obvious dose-effect and time-effect relationships. The effect of the glabridin in inhibiting the proliferation of the RA-FLS cells is related to the induction of apoptosis, and the glabridin can be used for obviously up-regulating the expression of caspase-3 and caspase-9 genes in the RA-FLS cells and down-regulating the expression of Bcl-2 genes. The glabridin has the potential of being developed into rheumatoid arthritis treatment medicine preparations with good curative effect and high safety and has comprehensive development and application prospects.

Description

Technical field [0001] The present invention relates to the use of glycosis in the preparation of a drug for treating rheumatoid arthritis. Background technique [0002] Rheumatoid Arthritis, RA) is an autoimmune disease with symmetrical, erosive and carnival inflammation, and its main pathology is characterized by abnormal hyperplasia and invasion and chronic inflammation of joint synthesis. And angioplasty formation. Epidemic survey shows that RA global incidence is 0.5 ~ 1%, China's incidence rate is 0.5%; with the prolongation of the course, RA leads to joint angioplasty formation and synovial hyperplasia to cause joint cartilage and osteoponal damage, which ultimately leads to joints Deformity and dysfunction, more than 10 years of disability rate of more than 50%. Ra not only causes the patient's physical obstacles, but also causes the social and family to have a heartbeat and economic burden, referred to as "undead cancer." Existing drugs for therapeutic RA mainly include:...

AI Technical Summary

Problems solved by technology

Licorice root is one of the most frequently used traditional Chinese medicinal materials in the adjuvant treatment of RA with traditional Chinese medicine. Its main active ingredients are triterpenoids, flavonoids and polysaccharides, etc., but there is no research on the active ingredients in it that can be used alone in the treatment of rheumatoid arthritis. to report

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