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Betaine salicylic acid eutectic crystal as well as preparation method and application thereof

A technology of salicylic acid and betaine, which is applied in the field of cosmetics and medicine, can solve skin and eye irritation problems, achieve the effects of reducing allergies, adjustable particle size, and reducing irritation

Active Publication Date: 2021-11-09
SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But betaine salicylate has certain irritation, which can cause irritation to skin and eyes. Therefore, the application of betaine and salicylic acid in medicine and cosmetics needs to be improved

Method used

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  • Betaine salicylic acid eutectic crystal as well as preparation method and application thereof
  • Betaine salicylic acid eutectic crystal as well as preparation method and application thereof
  • Betaine salicylic acid eutectic crystal as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] A kind of preparation method of betaine salicylic acid co-crystal provided by the invention comprises the following steps:

[0035] S1 Add solvent, betaine, and salicylic acid to the autoclave, add solvent, betaine, and salicylic acid to the autoclave, and stir under the first pressure and first temperature to form a suspension of betaine and salicylic acid liquid.

[0036] Specifically, the solvent can be liquid CO 2 , petroleum ether and ethyl acetate, etc. Among them, liquid CO is preferred 2 , liquid CO 2 It is non-toxic, non-flammable and moderately priced. The molar ratio of betaine to salicylic acid is 1:1, and the solid-to-liquid ratio of the sum of betaine + salicylic acid to the solvent is 1:4-1:6 (kg:L). An autoclave refers to a reactor operated under high pressure. The pressure of the autoclave is set to 10-30MPa, preferably 20MPa; the temperature is set to 110-130°C, preferably 115°C; the stirring speed is 600-750r / min, preferably It is 700r / min; the ...

Embodiment 1

[0045] A kind of preparation method of betaine salicylic acid eutectic:

[0046] S1 Add liquid CO to the autoclave 2 , betaine, and salicylic acid, wherein the molar ratio of betaine and salicylic acid is 1:1, and the solid-to-liquid ratio of the sum of betaine + salicylic acid to the solvent is 1:5 (kg: L). The pressure of the autoclave is set to 20MPa, the temperature is set to 115°C, the stirring speed is 700r / min, and stirred for 4h to form a suspension of betaine and salicylic acid;

[0047] S2 pumps the suspension from a high-pressure pump to a high-pressure homogenizer, passes through a homogenizing valve, and sets the pressure of the homogenizing valve to 800 bar;

[0048] S3 depressurizes the receiving chamber of the homogenizer to normal pressure at normal temperature, so that the liquid CO 2 Volatilize to obtain betaine salicylic acid eutectic.

[0049] Schematic diagram of the molecular structure of betaine salicylic acid cocrystal as figure 1 As shown, the mol...

Embodiment 2

[0197] The difference from Example 1 is that the pressure of the homogeneous valve in S2 is set to 600 bar. The single crystal data and hydrogen spectrum data of the betaine salicylic acid cocrystal tested are the same as those in Example 1, and the purity exceeds 98%.

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Abstract

The invention provides a betaine salicylic acid eutectic crystal as well as a preparation method and application thereof, and relates to the technical field of medicines and cosmetics. The invention relates to a betaine salicylic acid eutectic crystal. The betaine salicylic acid eutectic crystal is an orthorhombic system; the space group is Pbca; the cell parameters are as follows: a=10.2107(8) Angstroms, b=10.7746(8) Angstroms, c=22.5314(17) Angstroms, alpha = beta = gamma = 90 degrees, and Z = 8; and the cell volume V is equal to 2478.8(3) Angstrom<3>. The betaine and salicylic acid eutectic crystal provided by the invention can improve the irritation problem of betaine salicylate.

Description

technical field [0001] The invention relates to the technical fields of medicine and cosmetics, in particular to a co-crystal of betaine salicylic acid and a preparation method and application thereof. Background technique [0002] Beta-hydroxy acids (BHAs) in salicylic acid are similar to alpha-hydroxy acids (AHAs), and have the function of accelerating the exfoliation of scaly keratinocytes. Salicylic acid belongs to aromatic beta-hydroxy acids, and its efficacy in skin care products It has already been fully recognized by people. In the field of medicine, salicylic acid can be used to treat acne through topical administration; in the field of cosmetics, it can improve the fine lines and wrinkles caused by the aging of the body's internal functions, as well as the wrinkles, sagging, and spots caused by photoaging. question. [0003] The function of trimethylglycine in betaine in skin care has also been used in the cosmetics industry for a long time. It can enhance the mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/12C07C65/10C07C227/42C07C51/43A61K31/205A61K31/60A61P29/00A61P17/00A61P17/10A61P17/18A61P31/04A61K8/368A61K8/44A61Q17/00A61Q17/04A61Q19/00A61Q19/10
CPCC07C229/12C07C65/10A61P29/00A61P17/00A61P17/18A61P17/10A61P31/04A61K8/44A61K8/368A61Q17/005A61Q17/04A61Q19/10A61Q19/00C07B2200/13
Inventor 张嘉恒王振元韩知璇干瑞靖李雪云王天晓吴称玉
Owner SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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