Structured molecular vectors for anti-inflammatory compounds and uses thereof
A technology of compounds and hydrates, applied in phosphorus organic compounds, anti-inflammatory agents, compounds of Group 5/15 elements of the periodic table, etc.
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Embodiment A
[0382] Example A: Synthesis
[0383] Synthesis of I.1.SSL-X compound (n=0)
[0384] 1. bio-based approach
[0385] The synthesis of SSL-X was performed using ceramide aminoethylphosphonate (CAEP), which is relatively abundant in certain marine organisms, especially bivalve molluscs such as the blue mussel (Mytilus galloprovincialis). For this purpose, total lipids were extracted and purified according to the Folch method (Folch J., Lees M. and Stanley G.H.S., (1957), A simple method for the isolation and purification of total lipids from animal tissues of total lipids from animal tissues), J. Biol. Chem. 226, 497-509). The lipids are then saponified. After purification of the unsaponifiable lipid fraction, the CAEP was deacylated using strong basic or acidic hydrolysis. The deacylated CAEP was then purified and quantified. SSL-X1, SSL-X2 and SSL-X3 were then synthesized by N-acylation. figure 1 The synthesis procedure is shown.
[0386] The detailed procedure for SS...
Embodiment B
[0429] Example B: Biological Results
Embodiment B-1
[0430] Example B-1: Metabolic fate of SSL in the digestive tract
[0431] Materials and methods
[0432] animal
[0433] Rats used in our experiments were Sprague Dawley male rats (Charles River, Saint Germain sur L'Arbresle, France), ~200 g upon receipt at an approved animal facility, maintained at a temperature of 21 °C and diurnal conditions ( The light period is from 06:00 to 18:00). The rats were divided into groups of 5 individuals in each cage, and water and food were taken ad libitum. All animal testing procedures comply with European Directive 86 / 609 transposed into French law by Decree 87 / 848. Every effort is made to minimize animal suffering and stress and to reduce the number of animals used. Animals were used two weeks after arrival at the animal facility.
[0434] Administering SSL to Animals
[0435]Research on the fate of SSL in the digestive tract was performed on SSL-X1. For this, an aliquot of SSL-X1 corresponding to 227 μg of lipid phospholip...
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