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Experimental mouse hyperlipidemia model feed formula, preparation method, feeding method and device

A technology of hyperlipidemia and feed formula, which is applied in the field of experimental animals, can solve the problems of ignoring high fat, long modeling time, non-compliant feeding time and quantity, and achieve the effect of reducing interference

Pending Publication Date: 2021-12-03
江苏省协同医药生物工程有限责任公司
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. It takes a long time to build the model and the model is not complete enough. Experimental mice can be divided into rats and mice. In all literature reports using rats to create hyperlipidemia models, the modeling time takes 4 to 8 weeks. It takes 8 to 20 weeks to make a model of hyperlipidemia using mice, and the blood indicators often cannot fully meet the requirements, that is, the model is not perfect
In terms of processing technology, the preparation of model feed follows the traditional feed processing method, ignoring the characteristics of high fat, resulting in fat loss and shapeless feed
[0009] 5. The feeding method is basically controlled by humans, and the feeding time and quantity are often not in compliance, which leads to the inability of the experimental mice to form a model quickly and completely, the degree of automation is extremely low, and there is no means of monitoring

Method used

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  • Experimental mouse hyperlipidemia model feed formula, preparation method, feeding method and device
  • Experimental mouse hyperlipidemia model feed formula, preparation method, feeding method and device
  • Experimental mouse hyperlipidemia model feed formula, preparation method, feeding method and device

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Embodiment 1

[0055] Example 1: The raw material ratio of the formula is as follows: 18% casein, 5% sucrose, 3% cellulose, 10% maltodextrin, 20% fructose, 0.25% L-cystine, 5% mineral mixture, Vitamin mix 1%, lard 25%, beef tallow 10%, butter 15%, cholesterol 2%, bile salts 0.65%, anti-caking agent 0.1%; the casein, sucrose and maltodextrin are processed by fine grinding , so that the passing rate of casein in the 100-mesh sieve will reach more than 98%, the passing rate in the 20-mesh sieve of the maltodextrin will reach more than 98%; the passing rate in the 60-mesh sieve of the sucrose will reach 99% above.

[0056] Example 1: The raw material ratio of the formula is as follows: 22% casein, 5% sucrose, 3% cellulose, 12% maltodextrin, 15% fructose, 0.5% L-cystine, 5% mineral mixture, Vitamin mix 1%, lard 5%, beef tallow 13%, butter 15%, cholesterol 2%, cholate 1%, anti-caking agent 0.5%; the casein, sucrose and maltodextrin are processed by fine grinding , so that the passing rate of cas...

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Abstract

The invention provides an experimental mouse hyperlipidemia model feed formula, a preparation method, a feeding method and device, electronic equipment and a storage medium. The preparation method comprises the following steps of: crushing, mixing and granulating through a scientific and reasonable unique raw material ratio; drying a primary product at low temperature until the moisture is 10 percent or below to obtain feed; and feeding rats with the feed for 2 to 4 weeks; feeding mice with the feed for 4 to 8 weeks to obtain model indexes of high-level triglyceride, high-level cholesterol and low-level high-density lipoprotein in blood. According to the experimental mouse hyperlipidemia model feed formula, the experimental mice can be scientifically fed in an automatic and customized feeding manner according to model index requirements; and the irregular condition of feeding time and quantity caused by manual control is avoided, so that the integrity and consistency of a model are facilitated, the success rate and efficiency of modeling are improved, various symptoms of human hyperlipidemia are simulated, and good experimental conditions are provided for research of human related diseases.

Description

technical field [0001] The invention relates to the field of experimental animals, in particular to a feed formula, a preparation method, a feeding method and a device for an experimental mouse hyperlipidemia model. Background technique [0002] Hyperlipidemia, which is what we usually call hyperlipidemia, is the appearance of indicators such as high triglycerides, high cholesterol, and low levels of high-density lipoprotein in human or animal blood, and can directly cause some diseases such as atherosclerosis, coronary heart disease, etc. Symptoms of heart disease and other diseases that seriously endanger human health. As far as animal models of lipemia are concerned, there are mainly mice, rabbits, birds, pigs, and non-human primates. Primates are most similar to humans, but they are difficult to achieve because they are rare and expensive. Therefore, in practical applications, animals such as mice and rats, which are practical, easy to raise and have a clear genetic bac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/50A23K20/147A23K20/163A23K20/142A23K20/20A23K20/174A23K20/158A23K40/10A01K67/02A01K1/03A01K1/035A01K7/02A01K5/02A01M23/04A01K1/00
CPCA23K50/50A23K20/147A23K20/163A23K20/142A23K20/30A23K20/174A23K20/158A23K40/10A01K67/02A01K1/031A01K1/0356A01K7/02A01K5/02A01M23/04A01K1/0082
Inventor 吴小马葛全金金灿
Owner 江苏省协同医药生物工程有限责任公司
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