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Application of betulinic acid to preparation of antidote for F-2 toxin poisoning, antidote and application of antidote

An antidote, betulinic acid technology, applied in the direction of application, antidote, non-central analgesic, etc., can solve the problems of increasing antioxidant enzyme activity, insufficient effect, single detoxification route, etc., to antagonize the toxicity of F-2 toxin Function, the effect of improving animal production performance

Pending Publication Date: 2021-12-24
HUNAN AGRICULTURAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] The antidote of F-2 toxin disclosed in the prior art is vitamin-E (VE). Although VE has a detoxification effect on F-2 toxin, its detoxification effect is mainly aimed at repairing the animal ovary induced by F-2 toxin. Oxidative damage to granulosa cells increases the activity of antioxidant enzymes, and its detoxification pathway is relatively single, and the effect is not comprehensive enough

Method used

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  • Application of betulinic acid to preparation of antidote for F-2 toxin poisoning, antidote and application of antidote
  • Application of betulinic acid to preparation of antidote for F-2 toxin poisoning, antidote and application of antidote
  • Application of betulinic acid to preparation of antidote for F-2 toxin poisoning, antidote and application of antidote

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[0026] The present invention also provides a preparation method of the antidote, comprising the following steps: grinding the active ingredients of the antidote to obtain the antidote. In the present invention, it is preferable to grind the active ingredients of the antidote after mixing; the grinding preferably also includes drying. The present invention has no specific limitations on the grinding method, the particle size of the ground material, the drying method and the water content of the antidote after drying.

[0027] The present invention also provides the application of the above-mentioned antidote or the antidote prepared by the above-mentioned preparation method in the preparation of antidote drugs or health care products for F-2 toxin poisoning. The mechanism of action described in the present invention is the same as above, and will not be repeated here.

[0028] The present invention also provides the application of the above-mentioned antidote or the antidote p...

Embodiment 1

[0032] An antidote for F-2 toxin poisoning, consisting of the following components: betulinic acid 470g (47 parts by weight), blueberry extract 150g (15 parts by weight), glycyrrhizin 150g (15 parts by weight), ganoderma polysaccharide 150g ( 15 parts by weight) and lycopene 70g (7 parts by weight).

[0033] Preparation of the antidote: mix betulinic acid, blueberry extract, glycyrrhizin, ganoderma polysaccharide and lycopene according to the weight ratio and grind them into powder to obtain the antidote.

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Abstract

The invention relates to the technical field of antidotes for F-2 toxin poisoning, in particular to application of betulinic acid to preparation of an antidote for F-2 toxin poisoning, the antidote and application of the antidote. The antidote prepared from betulinic acid can effectively inhibit the expression of estrogen receptors ERalpha and ERbeta in vivo and antagonize the estrogen-like toxic effect of F-2 toxin; and meanwhile, the antioxidant capacity and anti-inflammatory capacity of the uterus, the ovary and other functional organs such as the liver can be improved, and the toxic effect of F-2 toxin is comprehensively and effectively antagonized, so that the animal production performance is improved.

Description

technical field [0001] The invention relates to the technical field of antidotes for F-2 toxin poisoning, in particular to the application of betulinic acid in the preparation of antidotes for F-2 toxin poisoning, the antidotes and applications thereof. Background technique [0002] F-2 toxin, also known as Zearalenone (ZEA), is a non-steroidal mycotoxin produced by Fusarium. Toxic secondary metabolites mainly produced by mycotoxins such as Fusarium graminearum and Gibberella zea are one of the most common mycotoxins that contaminate food and are widely found in grain varieties (such as corn, wheat, sorghum, oats, soybeans) and In foods of animal and plant origin. F-2 toxin belongs to exogenous estrogen, its chemical structure is similar to natural estrogen such as 17β-estradiol (E2), and it can competitively bind to estrogen receptor (ER) to form homologous or heterologous polymer, and enter the nucleus from the cytoplasm to bind to estrogen receptor elements, thereby act...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K36/45A23L33/10A23L33/125A23L33/105A61P39/02
CPCA61K31/56A61K36/45A61K31/704A61K31/715A61K31/01A61P39/02A61P39/06A61P29/00A23L33/10A23L33/125A23L33/105A23V2002/00A61K2300/00A23V2200/30A23V2250/2106A23V2250/213A23V2250/252A23V2250/51
Inventor 邬静易金娥袁志航文利新李荣芳
Owner HUNAN AGRICULTURAL UNIV
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