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Functional organ preservation solution

A technology for sexual organs and preservation solution, applied in the field of 18β-glycyrrhetinic acid in the preparation of functional organ preservation solution, which can solve the problems of no relevant reports, achieve the effect of reducing the level, strong applicability, and improving kidney function

Inactive Publication Date: 2022-01-21
蒋亚梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report of HC-A solution in reducing the incidence of DGF

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1ml100U / mL heparin saline was injected intraperitoneally 30 minutes before operation. Afterwards, the small animal anesthesia machine was used for continuous gas anesthesia with isoflurane. After the anesthesia was stable, the mouse was fixed on the operating table, and the abdomen was sterilized with 75% alcohol. , down to the upper edge of the pubic bone, and cut horizontally along the lower edge of the costal arch.

[0032] The abdominal aorta was separated and blocked at its distal bifurcation; an indwelling needle was inserted into the abdominal aorta 0.5 cm below the left kidney and fixed as a perfusion opening, and the abdominal aorta proximal to the chest above the level of the kidney was blocked at the same time. Inject HC-A solution + 18β-glycyrrhetinic acid into the perfusion opening, perform gravity lavage, flow rate 12mL / min, pressure 7.8-9.8kPa, that is, 80-100cmH 2 O, and cut the inferior vena cava below the level of the renal vein as a drainage outlet. ...

Embodiment 2

[0034] 1ml100U / mL heparin saline was injected intraperitoneally 30 minutes before operation. Afterwards, the small animal anesthesia machine was used for continuous gas anesthesia with isoflurane. After the anesthesia was stable, the mouse was fixed on the operating table, and the abdomen was sterilized with 75% alcohol. , down to the upper edge of the pubic bone, and cut horizontally along the lower edge of the costal arch.

[0035] The abdominal aorta was separated and blocked at its distal bifurcation; an indwelling needle was inserted into the abdominal aorta 0.5 cm below the left kidney and fixed as a perfusion opening, and the abdominal aorta proximal to the chest above the level of the kidney was blocked at the same time. Inject HC-A solution into the perfusion opening for gravity lavage with a flow rate of 12mL / min and a pressure of 7.8-9.8kPa, that is, 80-100cmH 2 O, and cut the inferior vena cava below the level of the renal vein as a drainage outlet. Sufficient la...

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Abstract

The invention is suitable for the technical field of medical treatment, and provides an organ preservation solution and a kidney in-vitro preservation method. The organ preservation solution comprises the following components: an HC-A solution and 18beta-glycyrrhetinic acid, through combined use of the HC-A solution and the 18beta-glycyrrhetinic acid, the levels of renal injury markers and inflammatory factors can be reduced, and the renal function is improved. It is shown that the functional organ preservation solution combining the HC-A solution and the 18beta-glycyrrhetinic acid can effectively improve the kidney supply quality and reduce kidney injuries; particularly, the solution has a remarkable protection effect on transplanted donor kidneys which are statically cold-stored; the problem that an existing organ preservation solution is difficult to repair the kidney of a donor is solved, many marginal kidney donors are prevented from being discarded, and a large number of precious kidney sources are saved.

Description

1. Technical field [0001] The invention relates to a functional organ preservation solution, which belongs to the field of medical technology. Specifically, the invention provides the use and method of 18β-glycyrrhetinic acid in preparing a functional organ preservation solution. 2. Background technology [0002] Organ transplantation is currently one of the best ways to treat end-stage organ failure, and the quality of organ preservation plays a decisive role in the transplantation effect. Therefore, improving the organ preservation solution is receiving increasing attention in the field of organ transplantation. [0003] The existing organ preservation solution has been improved in response to long-term organ transportation, preservation, and low-temperature perfusion, which greatly improves the quality of grafts. Since the implementation of organ donation after the death of citizens in my country in 2015, circulatory death donor kidneys have been increasing, becoming one...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02A61K31/56A61P13/12A61P29/00
CPCA01N1/0226A61K31/56A61P13/12A61P29/00
Inventor 蒋亚梅朱同玉戚贵生其他发明人请求不公开姓名
Owner 蒋亚梅
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