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Application of Brusatol in preparation of anti-radiation injury medicine

An anti-radiation and drug technology, applied in the field of biomedicine, to achieve good social and economic benefits, strong anti-radiation damage, and significant anti-radiation effect

Active Publication Date: 2022-02-11
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no relevant report on the use of Brusatol in the prevention and / or treatment of radiation injury

Method used

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  • Application of Brusatol in preparation of anti-radiation injury medicine
  • Application of Brusatol in preparation of anti-radiation injury medicine
  • Application of Brusatol in preparation of anti-radiation injury medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1 Effect of Brusatol Prophylactic Administration on the Survival of Acute Radiation Injured Mice

[0086] 1. Experimental method

[0087] In order to study whether Brusatol has anti-radiation damage effect, with 60 Whole-body irradiation of Co γ-rays on C57BL / 6J mice was used as a model for experiments. Mice were divided into irradiation control group, Brusatol low-, middle- and high-dose administration groups, with 10 mice in each group, and mice were irradiated with 8.5 Gy whole body once. The three administration groups received intraperitoneal injection of Brusatol 1 day before irradiation (-1 d) and 3 hours before irradiation (-3 h), and the dosages were Brusatol 0.5 mg / kg, 1.0 mg / kg and 1.5 mg / kg kg, and the administration volume was 0.1 mL; the irradiation control group was injected with solvent 0.1 mL at the same time, the survival rate of mice 30 days after irradiation was observed, and the difference in survival rate between the Brusatol administrati...

Embodiment 2

[0090] Example 2 Effect of Brusatol Prophylactic Administration on Peripheral Blood of Acute Radiation Injured Mice

[0091] 1. Experimental method

[0092] In order to study the effect of Brusatol on the hematopoietic function of mice with acute radiation injury, 12 C57BL / 6J mice were divided into an irradiation control (IR) group and a Brusatol administration group, with 6 mice in each group, and the mice were irradiated with 6.5 Gy γ-rays all over the body . The mice in the Brusatol-administered group were administered twice a day (-1 day, -3 h) from 1 day before irradiation, and the dose of Brusatol was injected intraperitoneally each time at 1.0 mg / kg, and the administration volume was 0.1 mL; The group was injected with 0.1 mL of solvent at the same time. Peripheral blood images were detected 2 days before irradiation and 7 days, 10 days and 14 days after irradiation, respectively.

[0093] 2. Experimental results

[0094] see results figure 2, the results showed t...

Embodiment 3

[0095] Example 3 Prophylactic administration of Brusatol increases the number of hematopoietic stem and progenitor cells in the bone marrow of irradiated mice

[0096] 1. Experimental method

[0097] In order to study the effect of Brusatol on the number of hematopoietic stem and progenitor cells in irradiated mice, 12 C57BL / 6J mice were divided into an irradiation control (IR) group and a Brusatol administration group, 6 mice in each group, and the mice were irradiated with 6.5 Gy whole body gamma rays. The mice in the Brusatol-administered group were administered twice a day (-1 day, -3 h) from 1 day before irradiation, and the dose of Brusatol was injected intraperitoneally each time at 1.0 mg / kg, and the administration volume was 0.1 mL; The same period of injection of solvent 0.1 mL. The mice were sacrificed by cervical dislocation 14 days after irradiation, and nucleated cells from the femoral bone marrow were collected, and the number of hematopoietic stem and progeni...

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Abstract

The invention discloses an application of Brusatol in preparation of anti-radiation injury medicines, the invention discovers and verifies that Brusatol has a new application of anti-radiation injury for the first time, the lifetime and the survival rate of a mouse after radiation can be remarkably improved, and a pharmaceutical composition containing Brusatol can be used for preventing or treating acute radiation sickness, nuclear and radiation injury, radiation injury caused by tumor radiation therapy, and can also be used as a tool medicine for researching radiation injury resistance. The invention provides a brand new thought and strategy for research and development of radiation injury resistance medicines, and is wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. Specifically, the invention relates to the application of Brusatol in anti-radiation damage. More specifically, the present invention relates to the application of Brusatol in the preparation of anti-radiation damage drugs. Background technique [0002] With the rapid development of nuclear energy and nuclear technology, it has been widely used in various fields such as industrial and agricultural production, medical and health care, scientific research and national defense, and the opportunities for people to be exposed to ionizing radiation are also increasing. While bringing great convenience and benefits, it also brings radiation hazards that cannot be ignored. Nuclear leakage accidents, as well as civil radioactive sources, medical exposure, etc., may cause personnel to be exposed to radiation due to poor management or operational errors. Acute Radiation Sickness (ARS), collectively kno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61K36/185A61P17/16A61P7/00A61P1/00A23L33/105A61K8/49A61Q19/04
CPCA61K31/366A61K36/185A61P17/16A61P7/00A61P1/00A23L33/105A61K8/498A61Q19/04A23V2002/00A23V2200/30A23V2250/21
Inventor 余祖胤张雪文邢爽申星张恩琦
Owner ACADEMY OF MILITARY MEDICAL SCI
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