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Methods and compositions for improving enamel hardness and resistance

A technology of composition and mixture, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc.

Pending Publication Date: 2022-03-11
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, few attempts have been made to mitigate tooth loss due to physical aggression by altering the chemical structure of the tooth, since little is known about the physical wear process, especially from cracking and fatigue failure due to repeated loading

Method used

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  • Methods and compositions for improving enamel hardness and resistance
  • Methods and compositions for improving enamel hardness and resistance
  • Methods and compositions for improving enamel hardness and resistance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0130] Generalized Solution Process

[0131] All glassware was cleaned with a 1% Alconox solution, rinsed three times in tap water, three times in 1M-ohm residential DI water, and finally three times in 18.2M-ohm Millipore water. The glassware was air dried overnight at 20°C. Place 450 mL of 18.2M-ohm Millipore water in a beaker with a stir bar. Add calcium source and phosphate source to beaker with water, start stir bar. For example, in Example 1, calcium hydrogen phosphate anhydrous (CaHPO 4 ) with a target concentration of 0.01M. CaHPO 4 Acts as a source of calcium and phosphate. Therefore, in Example 1, the CaHPO of 0.6803g 4 Add to beaker. In all examples, due to undissolved and suspended CaHPO 4 , the solution is cloudy.

[0132] A pH meter (719S Titrino, Metrohm AG, Herisau, Switzerland) was calibrated by testing two solutions with a known pH between pH 3 and pH 7 according to the manufacturer's instructions. Adjust the suspended CaHPO by slow dropwise addit...

Embodiment 1

[0240]

Embodiment 2

[0242]

[0243] Table 3. Precipitated Coatings

[0244]

[0245] Table 3 shows the concentrations of calcium and phosphate ions that can form precipitates on the tooth enamel surface (expressed as -log([Ca 2+ ]×[PO 4 3- ])value. For example, no precipitate was formed in Comparative Examples 1-17, despite showing increased resistance to corrosive acids and / or carious acids. Comparative Examples 18-20 precipitated calcium phosphate compounds on the tooth enamel surface, but within about 16 hours (and / or overnight). Surprisingly, corresponding to image 3 Invention Example 1 and Invention Example 2 of the shaded area precipitate calcium phosphate compounds on the tooth enamel surface in 1 hour or less. Has the same pH as Inventive Examples 1 and 2, but has a slightly lower -log([Ca 2+ ]×[PO 4 3- ]) value of Comparative Example 21 did not form a precipitate coating on the tooth enamel surface. Thus, although a -log([Ca 2+ ]×[PO 4 3- ]) values ​​did not produce ...

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Abstract

The present invention relates to methods and compositions for exchanging ions in dental enamel. The teeth may be hardened and become more resistant to acid damage if treated with a composition that allows mineral supplementation and demineralization of minerals present in the teeth, for example by an aqueous oral care composition for demineralization and mineralization of at least one tooth, comprising: a source of calcium; a phosphate source; a fluoride source, preferably wherein the fluoride source provides a fluoride ion concentration of less than about 100 ppm, more preferably wherein the fluoride source comprises sodium fluoride, stannous fluoride, sodium monofluorophosphate, fluorinated amine, or a mixture thereof; at least 75% water by weight of the oral care composition; wherein the composition is supersaturated with respect to octacalcium phosphate, the composition having a viscosity of greater than about 2.75-log ([Cat; 2 + gt; ] * [P04lt; 3gt; ]) value, and the composition has a pH of from about 5 to about 6. Ion exchange in hydroxyapatite into fluoride or other metal ions can result in the teeth being more resistant to chemical and physical infringement.

Description

technical field [0001] The present invention relates to methods and compositions for exchanging ions in tooth enamel to increase the resistance of tooth enamel to exposure to physical and chemical insults of the oral cavity in an unexpectedly short period of time during the life of a subject. The present invention also relates to methods and compositions capable of depositing particle coatings on enamel surfaces to increase the resistance of the enamel surfaces to exposure to physical and chemical aggressions of the oral cavity in an unexpectedly short period of time during the life of the subject. The present invention also relates to an aqueous oral care composition having calcium, phosphate and fluoride, wherein the composition is supersaturated with respect to octacalcium phosphate, having a -log([Ca 2+ ]×[PO 4 3- ]) value, and a pH of about 5 to about 6. Background technique [0002] Enamel has both an organic and an inorganic phase. The organic phase is composed of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/21A61K8/19A61K8/24A61Q11/00
CPCA61K8/21A61K8/19A61K8/24A61Q11/00
Inventor A·A·拜格A·R·比斯布洛克S·J·圣约翰
Owner PROCTER & GAMBLE CO
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