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Individualized detection method for antipsychotic drugs

A technology of antipsychotic drugs and detection methods, applied in the field of precision pharmacy

Inactive Publication Date: 2022-03-15
PEOPLES HOSPITAL OF HENAN PROV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the main means of controlling mental disorders is drug treatment, but there are obvious individual differences in drug treatment, and individualized treatment of antipsychotic drugs is very important

Method used

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  • Individualized detection method for antipsychotic drugs
  • Individualized detection method for antipsychotic drugs
  • Individualized detection method for antipsychotic drugs

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Embodiment Construction

[0041] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, and are not intended to limit the present invention.

[0042] Aiming at the problems existing in the prior art, the present invention provides an individualized detection method for antipsychotic drugs. The present invention will be described in detail below in conjunction with the accompanying drawings.

[0043] Such as figure 1 As shown, the antipsychotic drug individualized detection method nucleic acid extraction step that the present invention implements comprises:

[0044] S101, collect the blood sample, discard the serum, take about 0.5ml blood clot and put it into the liquefaction column CX1, centrifuge at 12000rpm for 1 minute, add about 2 times the v...

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Abstract

The invention belongs to the technical field of precision pharmacy, and discloses an antipsychotic individualized detection method, which comprises: collecting a patient blood sample, and carrying out nucleic acid extraction by using a nucleic acid extraction kit; performing gene test analysis on the extracted nucleic acid sample to obtain a gene detection analysis result; on the basis of a gene detection result, a suitable antipsychotic drug is recommended in combination with the evidence of the certifying medicine; collecting a blood sample of the patient before next administration; determining the valley concentration of the medicine by adopting a high performance liquid chromatography; judging whether the drug valley concentration is in a safe range or not; the administration dosage is adjusted based on the drug valley concentration and the gene detection result, and then individualized drug therapy is achieved. Individualized treatment of patients is expected to be achieved, the curative effect of the medicine is improved, and the adverse reaction of the medicine is reduced.

Description

technical field [0001] The invention belongs to the technical field of precision pharmacy and relates to an individualized detection method for antipsychotic drugs. Background technique [0002] Schizophrenia is a group of mental illnesses of unknown etiology, with many obstacles in thinking, emotion, behavior and incoordination of mental activities, which brings a heavy burden to patients and their families, and patients often require long-term antipsychotic drug treatment. Over the past few decades, China's economic development, ideology, and lifestyle have undergone tremendous changes, and the disease burden caused by mental illness has increased day by day. So far, mentally ill patients have accounted for almost 1% of the total number of people in the world, and their incidence in my country is about 17%, and it is increasing year by year. At present, the main means of controlling mental disorders is drug treatment, but there are obvious individual differences in drug t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6827C12Q1/6888G01N30/02G01N30/74
CPCC12Q1/6827C12Q1/6888G01N30/02G01N30/74C12Q2600/106C12Q2600/156C12Q2563/107C12Q2565/1015
Inventor 赵宁明赵晟喻
Owner PEOPLES HOSPITAL OF HENAN PROV
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