Application of inhibitor and pharmaceutical composition

A technology of inhibitors and compositions, which can be used in drug combinations, antipyretics, anti-inflammatory agents, etc., and can solve problems such as unclear mechanism of action
CN114259554APending Publication Date: 2022-04-01SHENZHEN INST OF ADVANCED TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENZHEN INST OF ADVANCED TECH
Publication Date
2022-04-01

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Abstract

The invention discloses application of an inhibitor in preparation of a medicine for treating discogenic pain and a medicine composition. The pharmaceutical composition is a beta-catenin protein and TCF7 transcription factor binding inhibitor and / or a Wnt / beta-catenin signal channel inhibitor. In combination with data of an embodiment part, the beta-catenin protein and TCF7 transcription factor binding inhibitor and / or the Wnt / beta-catenin signal channel inhibitor can achieve the effect of treating the discogenic pain based on the inhibition of the Wnt / beta-catenin signal channel.
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Description

technical field

[0001] The invention relates to the field of treatment of geriatric diseases, in particular to the application of an inhibitor and a pharmaceutical composition. Background technique

[0002] Discogenic pain mainly refers to low back pain caused by disc degeneration. In a broad sense, discogenic neck pain can include all neck, shoulder and arm pain caused by intervertebral disc disease, but many pains caused by it have corresponding disease names, such as cervical disc herniation, cervical disc degeneration and stenosis, and cervical spondylosis. In recent years, cervical discogenic pain (cervical discogenic pain) specifically refers to the pain caused by the internal disorder of the intervertebral disc, without radiating pain and segmental nerve dysfunction, and does not involve the adjacent spinal cord, nerve roots, and facet joints. Discogenic neck pain is one of the common causes of chronic, intermittent neck and shoulder pain.

[0003] Some clinical stu...

Claims

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