Composite morphine preparation and application thereof

Abstract

The invention discloses a composite morphine preparation which comprises the following components in parts by weight: 1000-3000 parts of magnesium threonate and 10-40 parts of morphine. Specifically, the composition comprises the following components in parts by weight: 1500-2000 parts of magnesium threonate and 10-20 parts of morphine. Specifically, the composition comprises the following components in parts by weight: 1800 parts of magnesium threonate and 10 parts of morphine. The composite morphine preparation is in a solid dosage form. The preparation has a good analgesic effect, can effectively relieve analgesic tolerance caused by morphine, reduce the dosage of morphine, avoid morphine addiction and remarkably relieve constipation reaction of patients, and has the advantage of small side effect. Therefore, the invention also provides application of the composite morphine preparation. Clinical experiments prove that the analgesic effect after magnesium threonate and morphine are combined is far better than that after morphine is independently taken, analgesic tolerance caused by morphine can be effectively relieved, morphine addiction can be avoided, and meanwhile the magnesium threonate and morphine combined medicine has the advantage of being small in side effect.

Description

technical field [0001] The invention relates to the technical field of medical pharmaceutical preparations, in particular to a compound morphine preparation and its application. Background technique [0002] Cancer is a widespread worldwide problem, and cancer pain is a common problem for cancer patients. Cancer pain is an important yet neglected public health problem in both developed and developing countries. Effective management of cancer pain, especially in patients with advanced cancer, is one of four priorities in the World Health Organization's (WHO) Comprehensive Cancer Programme. Therefore, for those patients suffering from severe pain suffering from advanced cancer, there is an urgent need for a strong analgesic to eliminate the patient's pain. [0003] As an effective analgesic, opioid preparations are optional and ideal drugs, which include the following two products: 1. Simple opioids, such as morphine, OxyContin, tramadol, and codeine tablets etc.; 2. Compou...

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Problems solved by technology

[0004] However, when opioid preparations are used, there are the following defects: long-term use has large side effects, especially the defects of constipation and intolerance. Patients who take opioid preparations for a long time will suffer from opioid tolerance. In order to achieve the purpose of treating pain, however, large doses of morphine can cause a series of toxic side effects in patients, such as: respiratory depression, nausea, constipation and dependence, etc.

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