Compound triamcinolone acetonide salicylic acid liniment

A technology of triamcinolone acetonide acetate and salicylic acid is applied in the pharmaceutical field to achieve the effects of improving the transdermal absorption rate, inhibiting the generation of impurities and improving the curative effect of use

Pending Publication Date: 2022-05-17
HANGZHOU FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the compound triamcinolone acetonide salicylic acid liniment with stable and controllable quality and good effect in treating psoriasis has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 of the present invention compound triamcinolone acetonide salicylic acid liniment F1

[0031] 0.05g triamcinol acetonide acetate, 2g chloramphenicol and 2g salicylic acid dissolved in an appropriate amount of 95% ethanol aqueous solution to give a pharmaceutical solution; 2ml of azotone, 3ml dimethyl sulfoxide and 10ml of propylene glycol dispersed in an appropriate amount of 95% ethanol aqueous solution to give an excipient solution; after the above-described pharmaceutical solution and excipient solution were mixed, continue to add 95% ethanol aqueous solution, volume to 100ml, fully mixed, i.e., to obtain a compound triamcinol acetonide salicylic acid liniment F1.

Embodiment 2

[0032] Example 2 of the present invention compound triamcinolone acetonide salicylic acid liniment F2

[0033] Adjust the skin impermeable agent ratio, the skin impermeable agent consisting of 2ml of azosterone and 3ml dimethyl sulfoxide in Example 1 is replaced with 1ml of nitridone and 4ml dimethyl sulfoxide, the remaining prescription and preparation process is the same as Example 1, i.e., to obtain the present invention compound triamcinolone salicylic acid liniment F2.

Embodiment 3

[0034] Example 3 of the present invention compound triamcinolone acetonide salicylate liniment F3

[0035] Adjust the skin permeator ratio, the skin impermeable agent consisting of 2ml of nitrotonone and 3ml of dimethyl sulfoxide in Example 1 is replaced with 4ml of nitrogen ketone and 1ml of dimethyl sulfoxide, the remaining prescription and preparation process is the same as Example 1, i.e., the present invention compound triamcinolone salicylic acid liniment F3.

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PUM

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Abstract

The invention relates to a compound triamcinolone acetonide salicylic acid liniment. Each 100ml of the liniment is prepared from the following components: 0.01 to 0.2 g of triamcinolone acetonide acetate, 1 to 5g of chloramphenicol, 1 to 5g of salicylic acid, 1 to 5ml of azone, 1 to 5ml of dimethyl sulfoxide, 5 to 20ml of propylene glycol and the balance of 95 percent ethanol aqueous solution. The compound triamcinolone acetonide salicylic acid liniment disclosed by the invention is remarkable in psoriasis treatment effect, stable and reliable in quality, simple in preparation process and capable of realizing industrial production.

Description

Technical field [0001] The present invention relates to the pharmaceutical field, specifically to a liniment for the treatment of psoriasis. Background [0002] Psoriasis is an immune-mediated chronic inflammatory skin disease characterized by red patches with distinctly demarcated, thickened patches covered with scales. According to studies, the incidence of psoriasis worldwide is 3%. According to its pathological characteristics and clinical manifestations, psoriasis is mainly divided into psoriasis vulgaris, pustular psoriasis, arthropathic psoriasis, and erythroderma psoriasis, the most common of which is psoriasis vulgaris. The main histological features of psoriasis vulgaris include hyperkeratosis or incomplete keratinization of cells in the epidermis, swelling and distortion of intradermal vascular vessels, and various inflammatory cell infiltrates infiltration, in which neutrophils infiltrating the epidermis form Munro micro-abscesses and spongy travel vesicles. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/60A61K9/08A61K47/20A61K47/22A61P17/06A61P29/00A61K31/165A61K31/58
CPCA61K31/58A61K31/60A61K31/165A61K9/0014A61K9/08A61K47/20A61K47/22A61P17/06A61P29/00A61K2300/00
Inventor 吴黎明
Owner HANGZHOU FIRST PEOPLES HOSPITAL
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