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Traditional Chinese medicine composition for treating rheumatoid arthritis as well as preparation method and application thereof

A composition and rheumatoid technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Pending Publication Date: 2022-05-31
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Medicinal wine is sweet and pungent, warm in nature, and has the effects of treating wind-cold-damp arthralgia, dispelling blood stasis, relieving pain, expelling wind and activating blood circulation, and is mainly used clinically to treat rheumatoid arthritis, and has anti-inflammatory and analgesic effects [Liu Zhiping, et al., Traditional Chinese Medicine Research progress on control technology and clinical application of medicated wine. Chinese National Folk Medicine, 2015.24(19): p.19-21]. The present invention provides a compatible traditional Chinese medicine composition with Achyranthes bidentata and Pangosaurus as monarch drugs, with 60% After soaking in alcohol, it is used to treat rheumatoid arthritis, and there is no literature report at present

Method used

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  • Traditional Chinese medicine composition for treating rheumatoid arthritis as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating rheumatoid arthritis as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating rheumatoid arthritis as well as preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0028] The preparation of the Chinese medicine composition medicated wine of embodiment 1 treatment rheumatoid arthritis:

[0029] Step 1, according to the calculation of 100% of the traditional Chinese medicine composition, weigh the following raw materials in parts by weight: Achyranthes bidentata 10%, Rhododendron 10%, Caulis chinensis 12%, Caulis chinensis 12%, Guizhi 12%, Eucommia 12%, five Add bark 11%, ground maple bark 11% and millennium health 10%, chop or pulverize into coarse powder, and place in a closed container.

[0030] Step 2, add 5 times the weight of the total weight of the traditional Chinese medicine composition to the coarse powder obtained in step 1 and then soak it, and shake the wine vessel frequently during the soaking period; wherein, the degree of the white wine is 60°, and soak for 5 days.

[0031] Step 3, filter out the medicinal liquid after soaking, squeeze the medicinal residues, combine the leachate with the squeezed liquid, let stand for 1 da...

Embodiment 2

[0032] The preparation of the Chinese medicine composition medicated wine of embodiment 2 treatment rheumatoid arthritis:

[0033] Step 1, according to the calculation of 100% of the traditional Chinese medicine composition, weigh the following raw materials in parts by weight: Achyranthes bidentata 11.5%, Rhododendron 10.5%, Caulis chinensis 10.5%, Caulis chinensis 10.5%, Cinnamon twig 11.5%, Eucommia 11.5%, five Jiapi 11.5%, Dimaple bark 11.5% and Millennium Jian 11%, chopped or crushed into coarse powder, placed in a closed container.

[0034] Step 2, add 7.5 times of the total weight of the traditional Chinese medicine composition to the coarse powder obtained in step 1 and then soak it, and shake the wine vessel frequently during the soaking period; wherein, the degree of the white wine is 55°, and soak for 10 days.

[0035] Step 3, filter out the medicinal liquid after soaking, squeeze the medicinal residues, combine the leachate with the squeezed liquid, let stand for 1...

Embodiment 3

[0036] The preparation of the Chinese medicine composition medicated wine of embodiment 3 treatment rheumatoid arthritis:

[0037] Step 1, according to the calculation of 100% of the traditional Chinese medicine composition, weigh the following raw materials in parts by weight: Achyranthes bidentata 12%, Rhododendron 12%, Caulis chinensis 10%, Caulis chinensis 10%, Cinnamomum twig 10%, Eucommia 10%, five Add skin 12%, ground maple skin 12% and millennium health 12%, chop or pulverize into coarse powder, place in a closed container.

[0038] Step 2, add 10 times the weight of the total weight of the traditional Chinese medicine composition to the coarse powder obtained in step 1 and then soak it, and shake the wine vessel frequently during the soaking period; wherein, the degree of the white wine is 50°, and soak for 14 days.

[0039] Step 3, filter out the medicinal liquid after soaking, squeeze the medicinal residues, combine the leachate with the squeezed liquid, let stand f...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. Wherein radix achyranthis bidentatae and rhizoma dioscoreae nipponicae are taken as monarch drugs, and caulis sinomenii, kadsura pepper stem, cassia twig, eucommia ulmoides, cortex acanthopanacis, anisetree bark and obscured homalomena rhizome are taken as compatibility. The traditional Chinese medicine composition can effectively reduce secretion of inflammatory factors, interleukin 6 (IL-6) and interleukin 1 beta (IL-1beta) in cell supernatant of rheumatoid arthritis synovial fibroblasts (MH7A) induced by tumor necrosis factors (TNF-alpha), and can effectively up-regulate expression of pro-apoptotic protein (Bax) / apoptosis inhibiting protein (Bcl-2), so that apoptosis of the MH7A cells is promoted; the traditional Chinese medicine composition has a good effect of treating rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating rheumatoid arthritis, a preparation method and application thereof. Background technique [0002] Rheumatoid Arthritis (RA) is a chronic, inflammatory, autoimmune disease. RA has a symmetrical attack, often manifested as joint swelling and pain, and unfavorable activities; its main pathological changes are synovial inflammatory cell infiltration, pannus formation, and advanced articular cartilage and bone tissue destruction leading to joint ankylosis, deformity, and mobility. Serious handicaps, or even complete loss of labor, etc. RA can occur at any age, but it mostly occurs in women aged 30-50, and the male-to-female incidence ratio is about 1:3. The incidence of rheumatoid arthritis in my country is about 0.2-0.4%. The pathogenesis of RA is still not clear yet. The clinical symptoms are diverse and the disabil...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P19/02A61P29/00
CPCA61K36/21A61K36/8945A61K36/59A61K36/67A61K36/54A61K36/46A61K36/254A61K36/57A61K36/888A61P19/02A61P29/00A61K2236/333A61K2236/51A61K2300/00Y02A50/30
Inventor 薛宏宇毛晨晨胡琪张大瑾宁一铭史美云许建强许湘雁王豫东
Owner DALIAN UNIV OF TECH
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