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Tripterygium wilfordii decoction dreg patch and preparation method thereof

A technology of tripterygium wilfordii and dregs, which is applied in the field of tripterygium wilfordii dregs patch and its preparation, can solve problems such as anemia and aplastic anemia, acute renal failure and even death, and the reduction of male sperm count, so as to improve safety, The effect of reducing adverse reactions and side effects and improving compliance

Inactive Publication Date: 2020-04-14
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition, long-term use of Tripterygium wilfordii has obvious toxic and side effects, and can easily cause irreversible lesions in human reproductive organs, liver, kidneys and other organs. Common toxic and side effects include: digestive system toxicity, such as nausea, vomiting, loss of appetite, abdominal pain, constipation, digestive system toxicity Ulcers; blood system toxicity, such as bone marrow suppression, and the reduction of white blood cells and platelets caused by it, and agranulocytosis, anemia, and aplastic anemia may occur in severe cases; reproductive system toxicity, such as female menstrual disorders, infertility, and male sperm count decrease , decreased fertility, adolescent gonad development disorders, etc.; liver toxicity, such as liver cell damage, necrosis; renal toxicity, such as oliguria, edema, hematuria, low back pain, etc. after taking the drug, acute renal failure or even death may occur in severe cases

Method used

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  • Tripterygium wilfordii decoction dreg patch and preparation method thereof
  • Tripterygium wilfordii decoction dreg patch and preparation method thereof
  • Tripterygium wilfordii decoction dreg patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Tripterygium wilfordii medicine dregs: Weigh 100g of 80-mesh tripterygium wilfordii medicinal material after coarse crushing, soak with 8 times the quality of water at room temperature for 30 minutes, then heat and reflux extraction for 120 minutes, filter to obtain tripterygium wilfordii medicine dregs, and bake in an oven at 80°C Dried until the water content of the tripterygium wilfordii dregs was 1%, and the dregs were crushed to 200 mesh powder to obtain 90 g of the tripterygium wilfordii dregs.

[0024] (2) Hot-melt pressure-sensitive adhesive matrix: heat 270g of styrene-isoprene-styrene block copolymer (SIS, purchased from Dongguan Chengming Adhesive Co., Ltd.) at 150°C for 2 hours, add 2.7 g of 1% menthol was stirred at 150° C. for 10 minutes to obtain 272.7 g of a hot-melt pressure-sensitive adhesive matrix.

[0025] (3) Tripterygium wilfordii plaster: take 90 g of tripterygium wilfordii medicine dregs prepared in step (1) and add it to 272.7 g of hot-melt...

Embodiment 2

[0027] (1) Tripterygium wilfordii medicine dregs: Weigh 100g of 100-mesh tripterygium wilfordii medicinal material after coarse crushing, soak with 10 times the quality of water at room temperature for 30 minutes, then heat and reflux for extraction for 180 minutes, filter to obtain tripterygium wilfordii medicine dregs, and bake in an oven at 80°C Dried to 1.5% water content of Tripterygium wilfordii medicinal residues, crushed to 200 mesh powder to obtain 87g of Tripterygium wilfordii medicinal residues.

[0028] (2) Hot-melt pressure-sensitive adhesive matrix: heat 435g of styrene-isoprene-styrene block copolymer (SIS) at 160°C for 3 hours, add 8.5g of menthol accounting for 2% of the mass of SIS, and heat it at 160°C Stir for 10 minutes at low temperature to obtain 443.5 g of hot-melt pressure-sensitive adhesive matrix.

[0029] (3) Patch: Take 87g of Tripterygium wilfordii medicinal residue prepared in step (1) and add it to the 443.5g hot-melt pressure-sensitive adhesive...

Embodiment 3

[0031] (1) Tripterygium wilfordii medicine dregs: Weigh 100g of 100-mesh tripterygium wilfordii medicinal material after coarse crushing, soak with 20 times the quality of water at room temperature for 30 minutes, then heat and reflux extraction for 240 minutes, filter to obtain tripterygium wilfordii medicine dregs, and bake in an oven at 80°C Dried until the water content of the tripterygium wilfordii dregs was 2%, and the dregs were crushed to 200 mesh powder to obtain 91 g of the tripterygium wilfordii dregs.

[0032] (2) Hot-melt pressure-sensitive adhesive matrix: heat 637g of styrene-isoprene-styrene block copolymer (SIS) at 170°C for 5 hours, add 19.11g of menthol accounting for 3% of the mass of SIS, and heat it at 170°C Stirring was carried out for 10 minutes to obtain 656.11 g of hot-melt pressure-sensitive adhesive matrix.

[0033] (3) Tripterygium wilfordii plaster: take 91 g of tripterygium wilfordii medicine dregs prepared in step (1) and add it to 656.11 g of h...

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Abstract

The invention discloses a Tripterygium wilfordii decoction dreg patch and a preparation method thereof. The Tripterygium wilfordii decoction dreg patch is prepared from decoction dregs obtained afterTripterygium wilfordii extraction and a hot-melt pressure-sensitive adhesive matrix, and the hot-melt pressure-sensitive adhesive matrix is composed of patch auxiliary materials and menthol, wherein the weight ratio of the menthol to the patch auxiliary materials is (0.01-0.03):1, and the weight ratio of the Tripterygium wilfordii decoction dregs to the hot-melt pressure-sensitive adhesive matrixis 1:(3-8). The Tripterygium wilfordii decoction dreg patch is prepared by adding 1-3% of menthol into the patch auxiliary materials and mixing the menthol and the patch auxiliary materials with the Tripterygium wilfordii decoction dregs, so that the anti-inflammatory and analgesic effects of Tripterygium wilfordii are improved, adverse reactions and toxic and side effects caused by medicines arereduced, and the safety of Tripterygium wilfordii clinical external medicines is improved.

Description

technical field [0001] The present invention relates to a kind of medicine of transdermal dosage form which can be used for rheumatoid arthritis, systemic lupus erythematosus and other rheumatic immune diseases, and has anti-inflammatory, analgesic and immunosuppressive effects, specifically tripterygium twig dregs patch and Its preparation method and application. Background technique [0002] Tripterygium wilfordii is the xylem of the root of Tripterygium wilfordii Hook.f. in the Euonymus family Tripterygium wilfordii. Its nature and flavor are bitter, pungent, cool, and highly poisonous. Rheumatoid immune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, etc. have remarkable effects. In clinical practice of traditional Chinese medicine, Tripterygium wilfordii decoction pieces are usually decocted and taken orally. The decoction dosage is 15-25g per day. After decoction, the dregs of Tripterygium wilfordii are generally discarded as garbage. Studies ha...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61K9/70A61K47/10A61K31/045A61P29/00A61P19/02A61P37/02A61P37/06
CPCA61K9/7023A61K31/045A61K36/37A61K47/10A61K2236/331A61P19/02A61P29/00A61P37/02A61P37/06A61K2300/00
Inventor 温成平丁兴红
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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