Reconstruction method of fluorescence molecular tomography based on magnetic particle imaging prior guidance

Abstract

The invention belongs to the field of fluorescent molecular tomography, and in particular relates to a fluorescent molecular tomography reconstruction method based on a priori guidance of magnetic particle imaging, aiming to solve the problem that the guidance mode has no specificity for tumors, low accuracy and precision, and cannot overcome FMT Depth-limited defects, resulting in low-quality FMT reconstructions when the light source is moved to depths. The invention includes: acquiring MPI-dimensional tomographic images, near-infrared fluorescence two-dimensional images and CT images; constructing an SIS that can accommodate a ROI area, and discretizing by using a finite element method; The system matrix is ​​obtained by forward model calculation, and the objective function is constructed; the objective function is iteratively solved by Laplace regularization matrix constraint, and the reconstruction result of fluorescence molecular tomography is obtained. The present invention uses MPI to guide FMT to reconstruct a targeted tumor model with complete morphological structure, clear tissue edges and accurate spatial position.

Description

technical field [0001] The invention belongs to the field of fluorescent molecular tomography, in particular to a method for reconstructing fluorescent molecular tomography based on a priori guidance of magnetic particle imaging. Background technique [0002] Fluorescence Molecular Tomography (FMT) makes up for the defect that two-dimensional fluorescence molecular imaging (FMI, Fluorescence Molecular Imaging) cannot provide three-dimensional spatial information. The specific fluorescence distribution of the probe in vivo was obtained, and then the location and structure of the tumor were reconstructed. However, due to the nonlinear relationship between the measured flux on the surface and the fluorescent source (i.e. tumor) in terms of spatial location and signal intensity, and the photon transmission in the tissue has complex and severe scattering and absorption effects, the fluorescent light source located in the deep The fluorescent photons that can reach the surface af...

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above-mentioned problems in the prior art, that is, the guided modality is non-specific for tumors, has low accuracy and precision, and cannot overcome the defect of limited FMT depth, so that the quality of FMT reconstruction is low when the light source moves to the depth. The invention provides a priori-guided fluorescent molecular tomography reconstruction method based on magnetic particle imaging, the method comprising:

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