Methods of treating psychological and cerebral diseases

A disease, psychological technology, applied in the field of mental illness, can solve problems such as lack

Pending Publication Date: 2022-06-07
UNIV OF MARYLAND BALTIMORE
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, evidence for the key serotonin receptors required for the beneficial effects of shrubin is lacking

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods of treating psychological and cerebral diseases
  • Methods of treating psychological and cerebral diseases
  • Methods of treating psychological and cerebral diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] method

[0037] All procedures were approved by the University of Maryland Baltimore Committee on the Use and Care of Animals and performed in full accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.

[0038] animal

[0039] Two groups of male C57Bl / 6J mice of the same series were used in this study and were housed indoors. They were 8 weeks old at the start of the experiment, maintained on a 12-h light / dark cycle (lights on at 7 am), and provided food and water ad libitum. Animals were housed in groups prior to the experiment, but were housed individually at the beginning of the behavioral and stress protocol until the end of the study. Balanced assignment of mice to experimental and control groups based on hedonic behavior assessed post-stress.

[0040] chronic compound stress

[0041] Chronic compounded stress is used to induce an affective apathy-like phenotype in animals (10). The chronic compound st...

Embodiment 2

[0057] result

[0058] Eight-week-old male C57Bl / 6J mice were exposed to a chronic compound stress paradigm and the hedonic state was analyzed by two desire-choice tasks involving different senses: a two-bottle sucrose preference test comparing 1% sucrose solution and water consumption, as well as the female urine sniff test comparing the interaction with swabs soaked in the urine of male mice and estrous female mice ( Figure 1A ).

[0059] Mice showed a strong preference for sucrose solution and female urine at baseline, and after 10-14 consecutive days of chronic compound stress, the preference for sucrose and female urine was significantly reduced ( Figures 1B-1C ). Mice were then given a single intraperitoneal (i.p.) injection of shududin (1 mg / kg).

[0060] Mice exposed to chronic compound stress showed a significant recovery in preference for sucrose solutions and female urine 24-48 hours after shrubin injection, whereas mice given saline vehicle injections mainta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention provides a method for preventing or treating psychological diseases. The serotonin agonist or the serotonin receptor agonist and the serotonin receptor 2A antagonist are separately, sequentially or simultaneously administered.

Description

[0001] Federal Funds Statement [0002] This invention was made with Government support under Grant No. MH086828 awarded by the National Institutes of Health. The government has certain rights in this invention. [0003] CROSS-REFERENCE TO RELATED APPLICATIONS [0004] This international application claims priority under 35 U.S.C. Section 119(e) to U.S. Provisional Application Serial No. 62 / 886,090, filed August 13, 2019, which is hereby incorporated in its entirety. technical field [0005] The present invention relates to the field of mental illness. More specifically, the present invention relates to methods of treating psychological and brain disorders by manipulating the serotonergic system of the brain. Background technique [0006] Psychedelic substances have been used by humans for psychoactive and medicinal purposes for thousands of years (1). Clinical studies have recently begun to provide evidence supporting their use as therapeutic agents for a number of neur...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4045C07D209/04A61K31/675A61P25/00
CPCA61K31/675A61K31/4045A61P25/00C07D209/16C07F9/5728A61K45/06A61K31/517A61K36/07A61P25/24A61K2300/00A61K36/062A61K31/36
Inventor S·汤普森
Owner UNIV OF MARYLAND BALTIMORE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap