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Compound extracted from hull and stem of yellow horn, extracting method and application

A technology of Wenguan husk and Wenguan huskside is applied in the directions of steroids, applications, medical preparations containing active ingredients, etc. The effect of improving brain function and inhibiting cancer cells in vitro

Inactive Publication Date: 2006-10-25
杨柏珍 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, so far, the sorbetia sorbifolium husk and fruit stalk are discarded objects, which have not been developed and utilized.

Method used

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  • Compound extracted from hull and stem of yellow horn, extracting method and application
  • Compound extracted from hull and stem of yellow horn, extracting method and application
  • Compound extracted from hull and stem of yellow horn, extracting method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Such as figure 1 As shown, the 2000g sorbifolia husk is crushed to a particle size of 30 meshes, extracted with ethanol with a concentration of 10 times the volume of the husk and 35% (V / V), the leaching temperature is 60°C, and the leaching time is 3 hour, stirring for 1 minute every 10 minutes during the leaching process, then filtering, reclaiming ethanol to obtain a concentrated solution, the concentrated solution is passed through 101 macroporous resin, and eluted with 35% ethanol to enrich active ingredients, remove impurities, and reclaim ethanol to obtain The concentrate was evaporated to dryness to obtain a brown solid, i.e. total saponins; the total saponins were dissolved in water, extracted with n-butanol, recovered n-butanol, and dried to obtain a brown powder, which was subjected to repeated silica gel column chromatography with chloroform / methanol=100: Gradient elution was carried out at 35-60, and the eluate was recovered and recrystallized to obtain abo...

Embodiment 2

[0046] Such as figure 1 As shown, the 2000g radishes radix radix radix stalks were crushed, extracted with 85% (V / V) n-butanol at a concentration of 8 times the volume of the stalks, the leaching temperature was 75°C, and the leaching time was 1 hour. Stir for 5 minutes every 20 minutes during the extraction process, then filter, recover n-butanol to obtain a concentrated solution, pass the concentrated solution through 101 macroporous resin, and elute with 85% n-butanol to enrich active ingredients, remove impurities, and recover n-butanol. Butanol was concentrated, and the concentrate was evaporated to dryness to obtain a brown solid, that is, total saponins; the total saponins were dissolved in water, extracted with n-butanol, recovered n-butanol, and dried to obtain a brown powder. After repeated silica gel column chromatography, chloroform / methanol=100:35-60 to carry out gradient elution, recover the eluate, and recrystallize to obtain about 45 mg of white needle crystal...

Embodiment 3

[0052] Grind 1000g sorbifolia husk and 1000g peduncle, extract with 50% (V / V) ethanol at a concentration 10 times the volume of the husk and stalk, the extraction temperature is 90°C, and the extraction time is 2 hours , stirring for 3 minutes every 15 minutes during the leaching process, then filtering, recovering ethanol to obtain a concentrated solution, passing the concentrated solution through 101 macroporous resin, and eluting with 50% ethanol to enrich active ingredients, remove impurities, and recover ethanol to obtain a concentrated solution The product was evaporated to dryness to obtain a brown solid, i.e. total saponins; the total saponins were dissolved in water, extracted with n-butanol, recovered n-butanol, and dried to obtain a brown powder. Gradient elution at -60 was carried out, the eluate was recovered, and recrystallized to obtain about 50 mg of white needle crystals, which was the target compound xanthanin.

[0053] Take the above extracted xanthophyllin ...

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Abstract

The present invention relates to the development and utilization technology of radix radix sorbifolium, specifically a compound extracted from radix radix sorbiflora husk and stalk and its extraction method and application. The method is as follows: pulverize the sorbifolia fruit shell and / or fruit stalk, extract with a solvent, filter, recover the solvent to obtain a concentrated solution, pass the concentrated solution through a macroporous resin, elute with a solvent, recover the solvent to obtain a concentrate, evaporate to dryness, Obtain a brown solid, that is, total saponins. Dissolve the total saponins in water, extract with n-butanol, and dry to obtain a brown powder. After silica gel column chromatography, gradient elution is carried out with chloroform / methanol = 100:35-60, and the eluent is recovered , refined, to obtain the target compound pistachioside; the compound can be applied to the preparation of anti-tumor drugs for the treatment of brain diseases and health food for the prevention and treatment of brain diseases and tumors.

Description

technical field [0001] The invention relates to the development and utilization technology of sorbifolia, in particular to a compound extracted from sorbifolia husk and stalk, an extraction method and application. Background technique [0002] Xanthoceras Sobifolia (Xanthoceras Sobifolia) belongs to Sapindaceae Xanthoceras. It is a unique woody oil plant in my country. It belongs to one kind and is mainly distributed in Liaoning, Inner Mongolia and Hexi Corridor in my country. Because of its drought resistance, cold resistance, and It has the characteristics of barrenness, salt and alkali tolerance, few pests and diseases, easy reproduction, early fruiting, large yield, long lifespan and windproof and sand-fixing. At present, more than 700,000 mu have been cultivated nationwide. [0003] The seed kernel of xanthus sorbifolium contains 60% oil, and the oil contains 14 kinds of unsaturated fatty acids, which can be used as edible oil. The kernel of Xantho sorbifolium is edible...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/704A61P35/00A61P25/00A23L1/30A23L33/105
Inventor 杨柏珍王松江赵从福
Owner 杨柏珍
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