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Array continuous preparing chromatography system and using method thereof

A chromatographic system and an array-type technology, which is applied in the field of array-type continuous preparation chromatography systems and large-scale multi-component continuous preparation chromatography systems. , easy to enlarge, avoid the effect of dynamic sealing problem

Inactive Publication Date: 2006-11-08
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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Problems solved by technology

Annular chromatography is suitable for the separation of multi-component systems, but it is difficult to scale up, and it involves the dynamic sealing of pressure-bearing parts and the impurity of products caused by the radial diffusion of solutes during the movement of the cylinder wall, so this The actual promotion of chromatography technology is more difficult

Method used

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  • Array continuous preparing chromatography system and using method thereof
  • Array continuous preparing chromatography system and using method thereof

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with drawings and embodiments. See figure 1 , the embodiment of the array type continuous preparative chromatographic system of the present invention comprises:

[0022] Array chromatographic column 1 is composed of 20-100 chromatographic columns with identical specifications;

[0023] The solvent storage container 9, the solvent pump 4, and the main solvent control valve 41, wherein the solvent storage container 9, the solvent pump 4, and the main solvent control valve 41 are connected in sequence through pipelines, and then connected to each column of the array chromatographic column 1 through the pipelines. The top inlet is connected;

[0024] The raw material storage container 10, the raw material pump 3, and the main feed control valve 31, wherein, the raw material storage container 10, the raw material pump 3, and the main feed control valve 31 are connected in sequence through pipelines, and t...

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Abstract

The present invention provides an array type continuous preparative chromatography system and a method for using the same. The system includes a separation part, a raw material delivery part, a solvent delivery part, a collection part and a control part, wherein the separation part includes an array chromatographic column, and the specifications are exactly the same. Consists of at least 2 chromatographic columns. When the solvent is continuously and evenly fed into each column of the array chromatographic column, the feeding control valve is controlled by the computer and the control cabinet of the control part, and the feeding mode of the simulated annular chromatography is switched sequentially, periodically and evenly. Each chromatographic column is fed, and the eluted products are collected by a special product collector for array chromatography controlled by the control part, and sent to each product storage container respectively. The system is suitable for continuous large-scale production of multiple components.

Description

technical field [0001] The invention relates to the field of large-scale multi-component continuous preparation chromatographic systems, in particular to the field of array type continuous preparation chromatographic systems. Background technique [0002] Chromatography is a technical system that separates the components in a mixture from each other through the different retention times caused by the different forces between the two phases. Chromatography can be divided into analytical-level chromatography and preparative-level chromatography according to its use. The former has a very low detection limit, can detect trace components contained in the mixture, and is mainly used for substance identification; the latter is mainly used for the separation and purification of active ingredients in substances, and is suitable for large-scale preparation and industrial production. Preparative chromatography can be divided into batch operation and continuous operation according to ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/58G01N30/46G01N30/84B01D15/08
Inventor 陈福明宋华
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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