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Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator

An antiviral drug, indole technology, applied in antiviral agents, pill delivery, pharmaceutical formulations, etc., can solve problems such as normal cell damage

Inactive Publication Date: 2007-05-23
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional antiviral preparations can kill virus-infected cells, but also cause great damage to normal cells, which seriously limits the application and promotion.

Method used

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  • Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator
  • Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator
  • Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Embodiment 1: the preparation of tablet

[0084] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add artificially synthesized indole-2,3-dione, and slowly heat to dissolve at 60°C in a magnetic stirrer, then gradually cool to form Needle-shaped orange-red crystals, repeat the above steps, and repeat the crystallization 3 times to reduce heavy metal ions. The indole-2,3-dione crystals were pulverized into powders passing through a 80-mesh sieve, and 50 mg of indole-2,3-dione, 125 mg of lactose, and 320 mg of starch were weighed out and mixed uniformly, granulated by a wet method, and dried. After granulation, it is mixed with 5 mg of magnesium stearate, and compressed into tablets to make tablets with a weight of 500 mg each.

Embodiment 2

[0085] Embodiment 2: the preparation of capsule

[0086] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add artificially synthesized indole-2,3-dione, and slowly heat to dissolve at 70°C in a magnetic stirrer, and then gradually cool to form needles. Form orange-red crystal, repeat above-mentioned steps, repeat crystallization 3 times, to reduce heavy metal ion. Grind indole-2,3-dione crystals into powders passing through an 80-mesh sieve, weigh 50 mg of indole-2,3-dione, 445 mg of starch, and 5 mg of magnesium stearate, mix well, and fill capsules. Made into capsules each containing 500mg.

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Abstract

An application of indole-2.3-bione in preparing the antiviral medicine for HIV, influenza virus, hemorrhagic virus and herpes simplex virus and the immunopotentiator is disclosed.

Description

technical field [0001] The present invention relates to the application of indole-2, 3-diketone (indole-2, 3-dine) in the preparation of antiviral or immune enhancer drugs. Background technique [0002] Viral infectious diseases are a large class of diseases that seriously endanger human health, especially the disaster caused by SARS virus to human beings again. Although people have been devoting themselves to research on antiviral therapy for nearly a century, the results have not been significant, and so far there are still few specific and effective antiviral compounds. Among them, there are many anti-virus measures, such as interfering with or blocking its influence on host cells in various aspects of virus-infected cells, and eliminating free viruses and virus-infected cells in the body by improving the immune function of the body to achieve the purpose of curing virus infection, but Antiviral treatment technology is far from reaching the level of fundamentally solving...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/404A61K9/20A61P31/12A61P31/16A61P31/18A61P31/22
Inventor 岳旺刘占涛王蕾仲伟珍杨志宏徐敏
Owner QINGDAO UNIV
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