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Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator

A technology of antiviral drugs and immune enhancers, which can be used in antiviral agents, pill delivery, pharmaceutical formulations, etc., and can solve problems such as normal cell damage

Inactive Publication Date: 2006-04-19
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional antiviral preparations can kill virus-infected cells, but also cause great damage to normal cells, which seriously limits the application and promotion.

Method used

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  • Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator
  • Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator
  • Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Example 1: Preparation of tablets

[0084] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add synthetic indole-2,3-dione, slowly heat to dissolve at 60°C in a magnetic stirrer, and then gradually cool to form Needle-shaped orange-red crystals, repeat the above steps, repeat the crystallization 3 times to reduce heavy metal ions. Crush the indole-2,3-dione crystals into powder that has passed through an 80-mesh sieve, weigh out 50mg of indole-2,3-dione, 125mg of lactose, and 320mg of starch, mix well, granulate and dry by wet method, After sizing, it is mixed with 5 mg of magnesium stearate and compressed into tablets with a weight of 500 mg per tablet.

Embodiment 2

[0085] Example 2: Preparation of capsules

[0086] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add synthetic indole-2,3-dione, slowly heat to dissolve at 70°C in a magnetic stirrer, and then gradually cool to a needle Shape orange-red crystals, repeat the above steps, repeat the crystallization 3 times to reduce heavy metal ions. Crush the indole-2,3-dione crystals into powder that has passed an 80-mesh sieve, weigh out 50mg of indole-2,3-dione, 445mg of starch, and 5mg of magnesium stearate, mix well, and fill the capsules. Prepare capsules each containing 500mg.

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PUM

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Abstract

An application of indole-2.3-bione in preparing the antiviral medicine for HIV, influenza virus, hemorrhagic virus and herpes simplex virus and the immunopotentiator is disclosed.

Description

Technical field [0001] The invention relates to the application of indole-2,3-dine in the preparation of antiviral or immune enhancer drugs. Background technique [0002] Viral infectious diseases are a large category of diseases that seriously endanger human health, especially the disaster caused by SARS virus to humans again. Although people have been committed to the research of antiviral therapy for nearly a century, the results have not been significant. So far, there are still few specific and effective antiviral compounds. There are many anti-viral measures, such as interfering with or blocking the impact of virus-infected cells on host cells, and improving the immune function of the body to eliminate free viruses and virus-infected cells in the body to achieve the purpose of curing virus infections, but Antiviral treatment technology is far from reaching the level of fundamentally solving the problem. Since the virus must multiply in living cells, the ideal antiviral drug...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61K9/20A61P31/12A61P31/16A61P31/18A61P31/22
Inventor 岳旺刘占涛王蕾仲伟珍杨志宏徐敏
Owner QINGDAO UNIV
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