Slow release antibiotics preparation of bioactive substance

Abstract

The present invention relates to an antibiotic preparation for absorbable and non-absorbable implants used in human and veterinary medicine for the treatment of local microbial infections in hard and soft tissues. This antibiotic preparation is a mixture, which is composed of at least an amphoteric component and an antibiotic component, an anhydrous organic auxiliary component, an inorganic auxiliary component and a biologically active auxiliary component. Representatives of the amphoteric components are alkyl sulfates, aryl sulfates, alkylaryl sulfates, cycloalkyl sulfates, alkylcycloalkyl sulfates, alkyl sulfamate, cycloalkyl Sulfamate, alkylcycloalkylsulfamate, arylsulfamate, alkyl arylsulfamate, alkylsulfonate, fatty acid-2-sulfonate, arylsulfonate , Alkyl aryl sulfonate, cycloalkyl sulfonate, alkyl cycloalkyl sulfonate, alkyl pyrosulfate, cycloalkyl pyrosulfate, alkyl disulfonate, cycloalkyl disulfonate acid salt, aryl disulfonate, alkylaryl disulfonate, aryl trisulfonate and alkylaryl trisulfonate, the antibiotic component is selected from the following antibiotics: aminoglycoside antibiotics, Lincosamide antibiotics, 4-quinolone antibiotics or tetracycline antibiotics. The antibiotic preparation of the present invention can sustainably release biologically active substances.

Description

technical field [0001] The present invention relates to an antibiotic preparation and multiple uses thereof. Background technique [0002] In human and veterinary medicine, the treatment of local microbial infections of soft and hard tissues requires high concentrations of local antibiotics in the area of ​​infected tissue. It has long been known that the continuous use of antibiotics has its own set of problems. When continuous medication is used, it is often necessary to use a very high dose of antibiotics in order to achieve an effective antibacterial concentration of antibiotics in the infected tissue. Thus, especially in the case of aminoglycoside antibiotics and tetracycline antibiotics, their kidney and ear toxicity can seriously damage the body. Therefore, it is easy for people to think of locally adopting the delivery method of antibiotics, or converting them into suitable long-acting dosage forms. [0003] Antibiotic slow-release depot systems for the treatment ...

AI Technical Summary

Problems solved by technology

In addition, the preparation method of this antimicrobial storage system has a non-trivial effect on the release response

Systems containing salts of poorly soluble antibiotics have the disadvantage that a specific form of salt must be synthesized for each antibiotic used prior to the manufacture of long-acting formulations