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Doxycycline vibramycin enteric soluble preparation for treating peridentitis

A technology of doxycycline and enteric-coated preparations, applied in the directions of tetracycline active ingredients, microcapsules, digestive system, etc., can solve problems such as local ulcers, and achieve the effect of ensuring full absorption

Inactive Publication Date: 2002-12-18
李大鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after doxycycline disintegrates in the stomach, the drug will be released rapidly, thereby forming a higher drug concentration in the local gastric mucosa, and then causing more common gastrointestinal reactions, such as: nausea, vomiting, diarrhea, etc., severe cases local ulcers

Method used

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Examples

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Embodiment Construction

[0007] The doxycycline enteric solution for treating periodontitis of the present invention has doxycycline hydrochloride, and the doxycycline hydrochloride is externally coated with an enteric coating, and the pH value of the lowest dissolution point of the enteric coating is 5.0 -6.0. The doxycycline hydrochloride is in the form of micropills, the diameter of which is 0.5-1.5mm, and the outer surface of the micropills is coated with an enteric coating with a pH value of 5.0-6.0 at the lowest dissolution point, and then put into capsules. The powder or granular doxycycline hydrochloride is placed in an enteric-coated capsule with a pH value of 5.0-6.0 at the lowest dissolution point. The doxycycline hydrochloride is a tablet, and the outer surface of the tablet is coated with an enteric coating with a pH value of 5.0-6.0 at the lowest dissolution point. The pH value of the lowest dissolution point of the enteric coating is 5.5. The pH value of the lowest dissolution point o...

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Abstract

The present invention provides a doxycycline vibramycin enteric prparation for curing periodontitis, it has doxycycline hydrochloride whose exterior is covered with enteric coating with lowest dissolution point and pH value of 5.0-6.0. Said ivnention can completely release out and dissolve out medicine in duodenum, and can prevent the doxycycline vibramycin from forming higher local medicine concentration in stomach, so that its oral administration does not produce gastrointestinal reaction and local ulcer.

Description

Technical field: [0001] The invention relates to the technical field of doxycycline enteric-coated preparations for treating periodontitis. Background technique: [0002] Doxycycline is a tetracycline antibiotic widely used clinically as an anti-infective drug. In recent years, doxycycline has also been used in the treatment of periodontitis. However, after doxycycline disintegrates in the stomach, the drug will be released rapidly, thereby forming a higher drug concentration in the local gastric mucosa, and then causing more common gastrointestinal reactions, such as: nausea, vomiting, diarrhea, etc., severe cases Even local ulcers occur. Invention content: [0003] The invention provides a doxycycline enteric-coated preparation for treating periodontitis, which can only disintegrate in the duodenum and completely release the dissolved drug, and can avoid the high formation of doxycycline in the stomach. The local drug concentration is low, so it will not produce gastr...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/65A61P1/02
Inventor 李大鹏梁泓李思
Owner 李大鹏
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