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Diacetylamino-acetoxy-ethylenediamine larg-volume injecta and preparation method thereof

A technology of ethylenediamine diacetaminoacetate and injection, which is applied in the field of large-capacity ethylenediamine diacetaminoacetate injection and preparation thereof, can solve the problems of endangering the life safety of patients, easily causing pollution, and high market price, and achieving The effect of not easy secondary pollution, easy operation, and reducing the burden on patients

Inactive Publication Date: 2003-06-11
陈义忠
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, the first volume of "National Drug Standards", where the local standards of chemical drugs have been upgraded to national standards, only contains the small injection form of "ethylenediamine diacetamidoacetic acid injection". Glucose injection is used after dilution, which is inconvenient to operate and easy to cause pollution during the preparation process. Therefore, clinical application often easily causes various adverse reactions, and in severe cases, it may lead to shock of the patient and endanger the safety of the patient's life.

Method used

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Embodiment 1

[0020] The specific embodiment embodiment 1: diacetamidoacetic acid ethylenediamine glucose injection and preparation method: raw material ratio: by 1000 bottles of weekly quantity

[0021] Ethylenediamine diacetamidoacetic acid 600g

[0022] Glucose 12500g

[0023] Water for injection 250000ml Preparation method:

[0024] 1. Dispose of pipelines and containers for liquid preparation one day in advance, and rinse with water for injection before use;

[0025] 2. Weighing: Accurately weigh 600g of ethylenediamine diacetinate and 12500g of glucose;

[0026] 3. Dosing: Add the weighed glucose into 50% of the dosing amount of water for injection, heat and stir to dissolve completely, add 0.05% of the dosing amount of activated carbon, heat and boil for 15 minutes, let cool to 70-80°C, Decarbonization through sand filter rod filtration;

[0027] 4. Dissolve ethylenediamine diacetamidoacetic acid with a small amount of water for injection at a temperature of abo...

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Abstract

The present invention discloses a diacetylamine aceticacid ethylenediamine large volume injection and its preparation method. It comprises 0.1-1.2% of diacelylamine aceticacid ethylenediamine and 98.8-99.9% of isotonic regulator, buffer, cosolvent and injection water, and can be made into the large injection with 100 ml, 250 ml and 500 ml, can be used for intravenous drip. Its operation is simple and convenient, and does not result in secondary pollution.

Description

technical field [0001] The invention relates to a large-capacity injection of ethylenediamine diacetylaminoacetate and a preparation method thereof. Background technique [0002] Ethylenediamine diacetamidoacetic acid used name: Xinningling; category: hemostatic drug, used to prevent and treat various causes of bleeding. It has a good curative effect on surgical bleeding, surgical bleeding, respiratory bleeding, facial bleeding, gynecological bleeding, hemorrhoid bleeding, urinary tract bleeding, cancer bleeding, gastrointestinal bleeding, and cerebral hemorrhage. It has been clinically verified that this product is efficient, safe, and easy to use, and its curative effect on various bleeding is better than that of commonly used hemostatic drugs such as Hemostatin, Hemophenic acid and Tranexamic acid. Especially in the current situation where the blood source is easily contaminated by various viruses, this product has more clinical promotion value. However, the first volum...

Claims

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Application Information

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IPC IPC(8): A61K31/195A61P7/04
Inventor 陈义忠
Owner 陈义忠
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