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Sesquiterpene ketone injection, preparing method and use thereof

A technology for injections and semiterpene ketones, which is applied in the direction of active ingredients of ketones, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problem of large average particle size of liposomes, insufficient storage stability and anticancer activity, no Give the data of the average particle size of liposomes, etc.

Inactive Publication Date: 2004-02-04
谢恬
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  • Abstract
  • Description
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Problems solved by technology

[0011] Chinese patent publication CN1110134A relates to liposome preparation process and preparation, wherein particularly describes the preparation method of elemene liposome injection and the elemene liposome injection obtained by the method, the encapsulation efficiency of elemene is up to More than 85%, but no data are given on the average particle size of liposomes
[0012] Chinese patent publication CN1221607A relates to the use of CO 2 The critical or supercritical method prepares the technology of fat-soluble drug liposome and prepared elemene liposome injection, although the encapsulation efficiency of the liposome of elemene is very high, but the average of liposome The particle size is also too large
[0013] The preparations disclosed in the above documents all have deficiencies in storage stability and anticancer activity.

Method used

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  • Sesquiterpene ketone injection, preparing method and use thereof
  • Sesquiterpene ketone injection, preparing method and use thereof

Examples

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preparation example 1

[0069] Preparation Example 1: Preparation of extracts containing sesquiterpene ketones by molecular distillation of volatile oil of Chuanyujin

[0070] Using 1000ml Chuanyujin volatile oil (contains about 15wt% gemarone) as raw material, it is refined by the MD-S80 molecular distillation instrument of Guangzhou Hanwei Electromechanical Company. The process conditions: distillation temperature 38~46℃, distillation pressure 75~92Pa , The film scraping speed is 300-320 rpm, the temperature of the condensing surface is 20-25℃, the temperature of the system is 20-25℃, the flow rate of the material is 15-30 ml / h, and the distillate is obtained. Only the distillate is collected and accumulated to a sufficient amount (About 500ml), continue molecular distillation. Distillation temperature is 48~62℃, distillation pressure is 35~75Pa, film scraping speed is 300-320 rpm, condensing surface temperature is 20~25℃, system is kept at 20~25℃, and the flow rate of this fraction is 15~30 ml / h, coll...

preparation example 2

[0071] Preparation Example 2: Preparation of extract from turmeric volatile oil

[0072] According to the same method as Preparation Example 1, 1000ml of turmeric turmeric oil (containing about 3wt% turmeric, about 2.88wt% aromatic turmeric and about 6.16wt% gemarone) was used instead of 1000ml of Chuanyujin volatile oil to obtain 110ml of turmeric + An extract with a total content of turmeric + aromatic turmeric ≥70wt%. The product is a zedoary turmeric extract (abbreviated as extract B) containing about 75% by weight of the above three sesquiterpene ketones and about 19% by weight of sesquiterpene.

preparation example 3

[0073] Preparation Example 3: Preparation of extract from Curcuma zedoary volatile oil

[0074] According to the same method as Preparation Example 1, 1000ml of Curcuma zedoary volatile oil (containing about 2.85% by weight turmeric, about 3.13% by weight of aromatic turmeric and about 7.00% by weight of gemmatone) was used instead of 1000ml of Chuanyujin volatile oil to obtain 110ml of gemma An extract with a total content of ketone + curcumone + aromatic curcumone ≥ 70wt%. The product is an extract of Curcuma zephylla (abbreviated as extract C) containing about 75% by weight of the above three sesquiterpene ketones and about 19% by weight of sesquiterpenes.

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Abstract

The present invention relates to the new types of plant extract containing germacrone, curcumone and / or arylcurcumone, that is, nano liposome type, precursor liposome type long-cycle liposome type, long-cycle nano liposome type, nano microemulsion type, venous emulsion type, nano liposome sphere type and fat emulsion type.

Description

Technical field: [0001] The present invention relates to a new injection dosage form containing plant extracts of sesquiterpene ketones, and more specifically to liposome dosage forms, nanoliposomal dosage forms, proliposomal dosage forms, and long-circulating liposome dosage forms of these preparations. , Long circulation nano liposome dosage form, nano microemulsion type, intravenous emulsion type, lipid nanosphere dosage form and fat emulsion type. The invention also relates to the preparation methods and uses of these dosage forms. Background technique: [0002] In recent years, many researchers in the field of anti-cancer natural medicine research have devoted themselves to studying the anti-cancer activity of paclitaxel, various isomers of elemene, turmeric extract, yujin extract, etc. and various preparation forms of these drugs . [0003] Elemene is a sesquiterpene compound found in some plants. Its Latin name is Elemenum, English name is Elemene, and its chemical name is...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/127A61K31/12A61P35/00
Inventor 李德山陈泽平
Owner 谢恬
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