Antalgic, drug addiction-stopping medication and its preparation method
A technology of medicament and injection, applied in the preparation of the medicament, in the field of detoxification and analgesic medicaments containing tetrodotoxin, which can solve the problems of large loss of toxin, influence on drug efficacy, strong adsorption, etc., achieve high yield and no drug production Dependency, low cost effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Example Embodiment
[0019] Example 1
[0020] This example is an example of tetrodotoxin purification.
[0021] Separate, extract and purify tetrodotoxin according to the following methods and steps:
[0022] 1. Take 10kg of puffer fish innards and ovaries, place them in a 50-liter stainless steel automatic homogenizer, stir the homogenate, centrifuge the homogenate in a centrifuge at a speed of 2000 rpm, and take the supernatant;
[0023] 2. Place the supernatant obtained in step 1 in a distillation vessel, control the vacuum degree to be not less than 0.1Pa, and perform vacuum distillation, and distill until it evaporates to dryness to obtain a solid;
[0024] 3. Dissolve 100 g of the solid obtained in step 2 in 500 mL of 30% (W%) acetic acid aqueous solution, add 95% ethanol to dilute to 75% alcohol, then filter and collect the filtrate;
[0025] 4. The filtrate in step 3 is distilled under reduced pressure in a distillation vessel, and the vacuum is controlled to be not less than 0.1Pa, and disti...
Example Embodiment
[0029] Example 2
[0030] This embodiment is an example of the agent of the present invention.
[0031] Accurately weigh 1 mg of pure tetrodotoxin in Example 1, dissolve it in 500 mL of 1% citric acid aqueous solution, dilute to 10,000 mL with distilled water, and mix well. At this time, the PH value of the drug is 6.0, which contains 0.1 μg / mL tetrodotoxin and 0.5 μg / mL citric acid.
[0032] The above-mentioned drugs were sterilized under cobalt irradiation for 10 minutes, and then bottled and sealed to prepare injections.
Example Embodiment
[0033] Example 3
[0034] This embodiment is another example of the agent of the present invention.
[0035] Accurately weigh 1 mg of pure tetrodotoxin in Example 1, dissolve it in 50 mL of 10% citric acid aqueous solution, and mix well. At this time, the PH value of the drug is 4.5, which contains 20μg / mL tetrodotoxin and 100μg / mL citric acid.
[0036] The above-mentioned drugs were sterilized under cobalt irradiation for 10 minutes, and then bottled and sealed to prepare injections.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap