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Antalgic, drug addiction-stopping medication and its preparation method

A technology of medicament and injection, applied in the preparation of the medicament, in the field of detoxification and analgesic medicaments containing tetrodotoxin, which can solve the problems of large loss of toxin, influence on drug efficacy, strong adsorption, etc., achieve high yield and no drug production Dependency, low cost effect

Inactive Publication Date: 2004-03-31
王开业
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The separation of TTX, the report of pure system are more, record the separation and extraction method of TTX as in the patent 96119454.5, have used activated carbon column processing technique in this method, because the adsorption force of activated carbon is strong, toxin loss is big, and yield is low, and After its treatment, only a mixture of tetrodotoxin homologues, that is, a crude extraction product, can be obtained, which directly affects the curative effect of the medicine made from it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] This example is an example of tetrodotoxin purification.

[0021] Separation, extraction and purification of tetrodotoxin according to the following methods and steps:

[0022] 1. Take puffer fish viscera and ovary 10kg, place in a 50-liter stainless steel automatic homogenizer to stir and homogenate, and the homogenate is centrifuged in a centrifuge at a speed of 2000 rpm, and the supernatant is taken;

[0023] 2. Place the supernatant obtained in step 1 in a distillation container, control the vacuum degree to not less than 0.1 Pa, carry out vacuum distillation, and distill until evaporated to dryness to obtain a solid;

[0024] 3. Dissolve 100 g of the solid matter obtained in step 2 in 500 mL of 30% (W%) acetic acid aqueous solution, then dilute with 95% ethanol until the alcohol degree reaches 75%, then filter, and collect the filtrate;

[0025] 4. Distill the filtrate in step 3 under reduced pressure in a distillation vessel, control the vacuum degree to be not l...

Embodiment 2

[0030] This example is an example of the medicament of the present invention.

[0031] Accurately weigh 1 mg of the pure tetrodotoxin in Example 1, dissolve it in 500 mL of 1% citric acid aqueous solution, add distilled water to dilute to 10000 mL, and mix well. At this time, the pH value of the drug was 6.0, and it contained 0.1 μg / mL of tetrodotoxin and 0.5 μg / mL of citric acid.

[0032] The above medicine is sterilized under cobalt irradiation for 10 minutes, and then bottled and sealed to prepare the injection.

Embodiment 3

[0034] This embodiment is another example of the medicament of the present invention.

[0035] Accurately weigh 1 mg of pure tetrodotoxin in Example 1, dissolve in 50 mL of 10% aqueous citric acid, and mix well. At this time, the pH value of the drug was 4.5, which contained 20 μg / mL of tetrodotoxin and 100 μg / mL of citric acid.

[0036] The above medicine is sterilized under cobalt irradiation for 10 minutes, and then bottled and sealed to prepare the injection.

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PUM

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Abstract

The invention relates to a drug rehabilitation and analgetic medicine and method for making the same, which comprises spheroidine, citric acid and distilled water. The medicine is highly effective, no drug dependency will be produced, no repetition will occur after ceasing application, so its adaptation human populations are wide.

Description

technical field [0001] The invention relates to a medicament for detoxification and analgesia, in particular to a medicament for detoxification and analgesia containing tetrodotoxin, and also relates to a preparation method of the medicament. Background technique [0002] Drug abuse, especially drug abuse, seriously endangers people's physical and mental health. The main drug they take is heroin. Heroin is a refined product of morphine, which is made by acylation of morphine. The traditional drug treatment of opioid dependent patients is a gradual drug withdrawal plan to eliminate the patient's physical dependence, in which opioid drugs with less dependence are used to replace those with strong dependence, which is the so-called decreasing substitution method. Methadone is a better alternative drug. It is an opioid receptor agonist. Because it lasts for a long time, the withdrawal symptoms are mild and short, and can completely relieve the withdrawal symptoms caused by morph...

Claims

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Application Information

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IPC IPC(8): A61K31/529A61P25/04A61P25/36
Inventor 林文翰
Owner 王开业
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