Measuring method of zedoary oil and borneol content in suppository

A method of determination, the technology of zedoary oil, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of weak specificity, complex components, mutual interference, etc., and achieve strong specificity, good separation effect, and good recovery test Effect

Inactive Publication Date: 2004-04-07
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
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Problems solved by technology

[0002] Baofukang Suppository is a variety recorded in Part One of the Chinese Pharmacopoeia 2000 edition. Its main components are zedoary oil and borneol, both of which are volatile components. It is not strong, and there is mutual interference in the determination, and the content determination of the other main component borneol is not specified in the suppository standard
This product is a traditional Chinese medicine preparation with complex ingredients, and the previous content determination methods cannot effectively control its main active ingredients

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0026] (1) Determination of the content of curcuma oil in Baofukang suppository:

[0027] Chromatographic conditions and system suitability test: polyethylene glycol (PEG)-20M is used as the stationary phase, a 0.53mm wide-bore capillary column is coated with a film thickness of 1.33 microns; the column temperature is programmed to rise from 150 to 200°C, and the initial temperature is 150°C After keeping for 10 minutes, increase the temperature by 2°C per minute to reach 180°C, and keep for 10 minutes, increase by 10°C per minute, and keep the final temperature at 200°C for 5 minutes. The number of theoretical plates should not be less than 10,000 based on the peak of curcumol.

[0028] Preparation of reference substance solution: Accurately weigh an appropriate amount of curcumol reference substance, add ethyl acetate to make a solution containing 2.4 mg per 1 ml, and obtain it.

[0029] Preparation of the test solution: Take 8.7 grams of Baofukang Suppository (5 capsules),...

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Abstract

The gas chromatographic method is used in measuring the zedoary oil and borneol content in suppository. The measurement method has powerful specialization, good separation effect, high linearity, high stability and high repeatability, and may be used in controlling the quality of the suppository effectively.

Description

[technical field] [0001] The invention relates to a method for determining the composition of medicines. [Background technique] [0002] Baofukang suppository is a variety recorded in the first part of the Chinese Pharmacopoeia 2000 edition. Its main components are zedoary oil and borneol, both of which are volatile components. The stability is not strong, and there is mutual interference in the determination, and the content determination of the other main component borneol is not specified in the suppository standard. This product is a traditional Chinese medicine preparation with complex ingredients, and the previous content determination methods cannot effectively control its main active ingredients. [Content of the invention] [0003] The purpose of the present invention is to find a method for separating and measuring the curcuma oil and borneol in the suppository, measure the content of the curcuma oil and borneol in the suppository, and effectively monitor its act...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/30
Inventor 陈容
Owner HAINAN BIKAI PHARM CO LTD
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