Technological method for extracting active principle of dragon's blood by supercritical fluid

A technology of supercritical fluid and active ingredients, applied in medical preparations containing active ingredients, organic chemical methods, solid solvent extraction, etc. Activity has not been clearly reported and other issues, to achieve the effect of high α-glucosidase inhibitory activity, convenient operation, and simple process

Inactive Publication Date: 2004-09-15
SHANGHAI UNIV
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Problems solved by technology

The Chinese invention patent with the patent number of 98110688.9 reports a traditional Chinese medicine preparation of blood dried blood for the treatment of diabetes and its preparation method. And the inhibitory activity has not been clearly reported, so the patent does not involve the extraction of the active ingredients of the traditional Chinese medicine blood jellyfish

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  • Technological method for extracting active principle of dragon's blood by supercritical fluid
  • Technological method for extracting active principle of dragon's blood by supercritical fluid

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Embodiment 1

[0036] Supercritical fluid extraction method A: put 2.5kg of blood dried blood powder after crushing and sieving into the extraction kettle, and the extraction solvent carbon dioxide is replaced by CO 2 Cylinder discharge, filtered, storage tank, in CO 2 After being cooled and liquefied in the storage tank, the high-pressure pump is used to increase the pressure to the set extraction pressure of 20MPa, so that the CO 2 Become a supercritical fluid state, CO 2The flow rate of supercritical fluid is 30kg / h. Under a certain extraction pressure, it is heated to the set extraction temperature of 45°C through a heat exchanger, and then sent to the extraction kettle to contact with blood dried blood powder for dissolution and extraction. The carbon dioxide fluid and the extract enter the separation tank I together for the first-stage analysis. The analysis pressure is 7MPa and the temperature is 60°C. After the first-level analysis is completed, the three-way analysis valve of the ...

Embodiment 2

[0038] Supercritical fluid extraction method B: put 2.5 kg of blood dried blood powder after crushing and sieving into the extraction kettle, and extract solvent carbon dioxide by CO 2 Cylinder discharge, filtered, storage tank, in CO 2 After being cooled and liquefied in the storage tank, the high-pressure pump is used to increase the pressure to the set extraction pressure of 20MPa, so that the CO 2 Become a supercritical fluid state, CO 2 The flow rate of supercritical fluid is 30kg / h. Under a certain extraction pressure, it is heated to the set extraction temperature of 45°C through a heat exchanger, and then sent into the extraction kettle to contact with the dried blood fine powder; at the same time, the methanol in the organic solvent storage tank is pumped into the extraction kettle through a high-pressure pump to serve as entrainment. Agent, according to requirements, adjust the flow ratio of methanol entrainer and carbon dioxide fluid, generally 15%. The organic s...

Embodiment 3

[0040] Supercritical Fluid Extraction Method C: 2.5 kg of blood dried blood fine powder after crushing and sieving, was firstly extracted with non-polar ineffective components of blood dried blood by the same method as in the above-mentioned embodiment 1 and embodiment 2 to obtain 2.36 kg of extract , and then use the extraction residue as a raw material to carry out polar supercritical extraction with organic solvent methanol to remove polar ineffective components, and finally obtain 1.90 kg of an extraction residue of active components of dried blood.

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Abstract

The invention relates to an extracting technique of natural Chinese medicinal herb Daemonorops draco B1., especially a processing method of separating effective components in Daemonorops draco B1. by supercritical fluid extraction. Its character: use CO2 to supercritically extract nonpolar ineffective components in Daemonorops draco B1., and at the same time, use organic solvent as entrainer to extract polar ineffective components in Daemonorops draco B1., and the effluence of supercritical fluid extraction has two-stage analytic courses, and finally the remainder in the extracting kettle is the effective component of Daemonorops draco B1.; it has higher alph-glucosidase inhibiting activity, able to be applied to prepare sugar decreasing drug.

Description

technical field [0001] The invention relates to an extraction process of a natural Chinese herbal medicine, especially a process for extracting and separating effective components of a traditional Chinese medicine with a supercritical fluid, and belongs to the technical field of preparation of Chinese herbal medicines. Background technique [0002] Dried blood is a precious traditional Chinese medicine known as the "Holy Medicine for Blood Invigoration". It is sweet, warm, salty and flat in nature, and has the effects of promoting blood circulation and removing blood stasis, reducing swelling and pain, and stopping bleeding and nourishing blood. Modern medical research shows that dried blood can improve the microcirculation of the body, adjust metabolism, and improve immune function. Clinical trials have shown that dried blood has the effect of lowering blood sugar and blood fat, and is a potential new generation of hypoglycemic drugs with great development value. Dracaena ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P3/10B01D11/02C07B63/00
CPCY02P20/54
Inventor 雍克岚吕敬慈俞蔚陈旭修姗姗
Owner SHANGHAI UNIV
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