Human protein phosphokinase 2A point mutanted lung cancer related antigen gene

Abstract

A human protein phosphatase site-2A alpha mutant gene sequence associated with lung cancer, the change from arginine to tryptophane in the polypeptide chain whose amino acid sequence is shown by SEQ ID No.2, and the process for preparing said DNA sequence are disclosed, which can be used for diagnosing and treating lung cancer.

Description

(technical field) [0001] The present invention relates to lung cancer-associated antigen mutant gene sequence, in particular to the coding gene of mutant human protein phosphatase 2A (protein phosphatase 2A, PP2A) α catalytic subunit. (Background technique) [0002] Lung cancer is one of the most common malignant tumors in human beings. In recent years, the morbidity and mortality have shown an obvious upward trend both at home and abroad, but there is still a lack of effective treatment methods. It is now believed that tumor is a malignant disease with multiple gene changes. Its occurrence and development are closely related to a series of tumor-related gene structure, function changes, and abnormal regulatory relationships. It is a multi-stage, multi-step, and multi-gene process. Protein phosphatase refers to a class of enzyme molecules that catalyze the dephosphorylation reaction of phosphorylated protein molecules. They exist corresponding to protein kinases and together...

AI Technical Summary

Problems solved by technology

However, there is no report on the discovery and cloning of the gene encoding the mutant version of the catalytic subunit of human protein phosphatase 2Aα in human lung cancer cells

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