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Full solid violet and red laser device used for photodynamic therapeutics

A technology of photodynamic therapy and lasers, applied in lasers, laser components, radiotherapy, etc., can solve the problems of purple and red two-color lasers that have not been found in photodynamic therapy, and do not involve photodynamic therapy.

Inactive Publication Date: 2005-05-25
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] To sum up, none of these research and technical approaches involve the application of photodynamic therapy. So far, no reports of purple and red dual-color lasers specially used for photodynamic therapy have been found.

Method used

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  • Full solid violet and red laser device used for photodynamic therapeutics
  • Full solid violet and red laser device used for photodynamic therapeutics
  • Full solid violet and red laser device used for photodynamic therapeutics

Examples

Experimental program
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Embodiment 1

[0049] A dual-period structure PPLN all-solid-state violet and red dual-color laser for photodynamic therapy was fabricated. A semiconductor diode laser (LD) 1 is used as the pump source, the output wavelength is 0.808μm, the maximum output power is 15W, Nd:YVO 4 1.064μm and 1.342μm anti-reflection coatings are coated on the front and rear surfaces of the crystal 4. The input mirror 3 is highly reflective to both 1.064μm and 1.342μm dual wavelengths, and highly transparent to 0.808μm. The cavity mirror 7 forms a 1.064 μm laser resonant cavity, and the acousto-optic switch 5 is placed in the cavity to obtain quasi-continuous 1.064 μm and 1.342 μm lasers. Outside the cavity, the temperature is adjusted, and the simultaneous output of purple and red two-color lasers is obtained at the matching temperature.

Embodiment 2

[0051] Make a dual-period structure PPLN all-solid-state violet and red dual-color laser for photodynamic therapy. The difference from Example 1 is that both ends of the PPLN 10 are coated with 1.064 μm and 1.342 μm anti-reflection coatings and visible light anti-reflection coatings. The input mirror 3 is coated with 1.064μm, 1.342μm and visible light high reflection film, the output cavity mirror 6 is coated with 1.342μm high reflection film, 1.064μm and visible light are coated with high transparency film, the output cavity mirror 7 is coated with 1.064μm high Reflective film, coated with high transmittance film for visible light. No need for sound and light switches. The double-period structure PPLN is placed in the resonant cavity formed by the input mirror 3 and the laser output cavity mirror 6 to realize frequency conversion in the cavity to obtain simultaneous output of purple and red two-color continuous wave lasers.

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Abstract

A full-solid violet-red laser device for photodynamic therapy features that a semiconductor laser device is used as pumping light source, the reflection reducing film is plated no the front and back surfaces of Nd doped crystal, the laser resonant cavity is composed of input lens and two cavity mirrors, an acoustooptical modulator is arranged in said cavity, and a PPLN crystal is arranged in a temp controlled furnace outside the cavity.

Description

Technical field: [0001] The invention relates to an all-solid-state violet and red two-color laser for photodynamic therapy, in particular to an all-solid-state violet and red two-color laser using double-structure lithium niobate crystals as frequency conversion crystals. Background technique: [0002] Photodynamic therapy (Photodynamic therapy; PDT) is a new gentle and painless treatment technology that uses laser light to identify and kill cancer cells, which came out in the early 1980s. The basic principle of PDT is: first inject specific photosensitive substances into the body during treatment, the photosensitive substances will selectively stay in the tumor tissue, and then irradiate with blue (or purple) light, the photosensitive substances in the tumor will produce fluorescence, which can Assist in the diagnosis of tumors and find the location and extent of tumors. Then irradiated with red light, the photosensitizer absorbs the light energy, and transfers the light ...

Claims

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Application Information

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IPC IPC(8): A61N5/067H01S3/08H01S3/0941H01S3/10H01S3/16
Inventor 何京良刘杰韩可桢范秀伟王慧田祝世宁朱永元
Owner SHANDONG NORMAL UNIV
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