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Ginseng saponin superhigh pressure extraction process

An extraction method and technology of ginsenosides, applied in the direction of steroids, organic chemistry, etc., to achieve the effects of short extraction time, high efficiency, and simple process operation

Inactive Publication Date: 2005-06-22
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of this invention is to propose a ginsenoside ultra-high pressure extraction method to overcome the defects of the current traditional ginsenoside extraction method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Different leaching pressure experiments

[0023] Accurately weigh 5 parts of 0.25g degreased material samples, add 25mL of ethanol with 70% concentration (i.e. solid-liquid ratio is 1g:100ml) to seal, seal and soak for 12h (hour), pressurize 100, 200, 300, 400, 500, 600MPa leaching, the pressure holding time is 2min (minutes), after pressure relief and filtration, measure the absorbance of the extract obtained by each sample, and calculate the extraction rate of ginsenosides in Table 1.

[0024] Table 1 Comparison of extraction yields under different pressures

[0025] Pressure (Mpa) Absorbance Yield (%)

[0026] 100 1.462 7.24

[0027] 200 1.486 7.36

[0028] 300 1.502 7.43

[0029] 400 1.506 7.45

[0030] 500 1.518 7.51

[0031] 600 1.504 7.44

Embodiment 2

[0033] Different solvent experiments

[0034] Accurately weigh 4 samples of 0.5g degreased material, add 25mL of water, 25mL of methanol, 25mL of 50% ethanol, and 25mL of water-saturated n-butanol (i.e. the solid-liquid ratio is 1g:50ml), seal and soak for 12h, pressurize 500MPa leaching, the holding time is 2min, the absorbance value of the extract obtained by measuring each sample is measured after pressure relief and filtration, and the calculated ginsenoside extraction rate is shown in Table 2.

[0035] Table 2 Comparison of extraction yields with different solvents

[0036] Solvent Absorbance Value Yield (%)

[0037] Water 1.148 5.68

[0038] 50% ethanol 1.442 7.14

[0039] Methanol 1.197 5.93

[0040] n-Butanol 1.393 6.90

[0041] Different solvents have different dissolution rates of saponins. Among the above solvents, ethanol has the characteristics of the highes...

Embodiment 3

[0043] Solvent Concentration Experiment

[0044] Accurately weigh 5 parts of 0.5g degreased material samples, add 25mL of ethanol with a concentration of 10%, 25%, 50%, 70%, and 90% (that is, the solid-liquid ratio is 1g: 50ml), seal and soak for 12h, add Leach at a pressure of 500 MPa, hold the pressure for 2 minutes, measure the absorbance of the extracts obtained by each sample after pressure relief and filtration, and calculate the extraction rate of ginsenosides as shown in Table 3.

[0045] Table 3 Comparison of extraction yields with different solvent concentrations

[0046] Ethanol concentration (%) Absorbance value Yield (%)

[0047] 10 1.272 6.30

[0048]30 1.413 6.99

[0049] 50 1.442 7.14

[0050] 70 1.518 7.51

[0051] 90 1.037 5.13

[0052] The concentration of ethanol, the extraction solvent, affects the dissolution rate of saponin, and choosing an app...

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PUM

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Abstract

The invention provides a ginseng saponin superhigh pressure extraction process which comprises, drying ginseng, integrating and passing 40 mesh sieve, charging trichloromethane or ethyl ether dissolvent into ginseng powder, carrying out backflow and degreasing for 3h, filtering and drying the filtration slag under normal temperature, charging water or ethanol, methanol, n-butanol organic solvent into the defatted material, mixing and sealing, steeping at normal temperature for 0-24h, loading the mixed material into high-pressure container, applying 100-6000 MPa pressure under normal temperature for leaching, sustaining the pressure for 1-5min, releasing pressure and filtering slag, and gathering filter liquor.

Description

Technical field: [0001] The invention relates to a technology for extracting ginsenosides from ginseng, in particular to a technology for extracting ginsenosides by using ultra-high pressure technology. technical background [0002] Ginseng (Panax ginseng C.A.Mey.) is a perennial herb of Araliaceae. It is a traditional precious Chinese medicinal material. Its main component is ginsenoside, which has high biological activity and medicinal value, and has anti-tumor and anti-arrhythmic properties. , Improve myocardial ischemia, invigorate qi, benefit lung, promote body fluid and quench thirst, soothe the nerves and improve intelligence. However, ginsenosides have complex structures and various types. How to quickly and efficiently extract and separate different saponins is an important research content for the modernization of traditional Chinese medicine. The traditional extraction methods mainly include: [0003] ①Water decoction method: Add 10 times the amount of distilled...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
Inventor 张守勤王长征陈瑞战窦建鹏席军吴华
Owner JILIN UNIV
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