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Oil emulsion inactivated vaccine for parvoviral diseases of pigs

A technology of parvovirus and inactivated vaccines, which is applied in antiviral agents, emulsion delivery, antibody medical components, etc., can solve the problems of poor vaccine stability, fast stratification and shelf life, and reduce the dosage of vaccines, so as to achieve rapid stratification , Improve the physical properties, the effect of poor stability

Inactive Publication Date: 2005-12-07
上海佳牧生物制品有限公司
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Problems solved by technology

[0006] The invention provides an optimized porcine parvovirus AEI inactivated vaccine, which solves technical problems such as poor stability, fast stratification and shelf life of the existing product vaccine by changing the formula of the oil adjuvant, and reduces the use of the vaccine dose

Method used

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Examples

Experimental program
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Embodiment Construction

[0014] A porcine parvovirus disease oil emulsion inactivated vaccine is prepared by adding inactivated porcine parvovirus (PPV) into an oil adjuvant and emulsifying the oil adjuvant. The oil adjuvant is 94% white oil and 6% Siben-80 Add aluminum stearate in the stabilized liquid of forming, and its add-on is that 100 milliliters stabilized liquid adds 2 grams of aluminum stearate.

[0015] The amount of aluminum stearate contained in the oil adjuvant is related to the stability of the vaccine, and multiple emulsification tests have been carried out to prove that when 1-1.5 grams are added to the stable solution composed of 100 milliliters of white oil and Siben-80, the vaccine passes After centrifugation at 3000r.p.m for 15 minutes, it can be divided into two layers. The upper layer is milky white, and the lower layer is light red. / 5-1 / 6; when adding 4 grams, the viscosity of the vaccine increases significantly, and a small amount of white precipitate will appear.

[0016] T...

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Abstract

The invention relates to an oil emulsion inactivated vaccine for parvoviral diseases of pigs, which is prepared by charging deactivated porcine parvovirus (PPV) into oil adjuvant for emulsion, wherein the oil adjuvant is prepared through charging aluminum tristearate into the stable solution of 94 wt% white oil and 6 wt% sorbitan mono-oleate-80, the charging amount being 2g of aluminum tristearate into each 100ml of the stable solution.

Description

Technical field: [0001] The invention belongs to the technical field of new veterinary biomedicine, in particular to an inactivated porcine parvovirus oil emulsion vaccine. Background technique: [0002] The original porcine parvovirus AEI (acetylethyleneimide) inactivated vaccine is a two-phase oil emulsion vaccine prepared by adding inactivated porcine parvovirus (PPV) to oil adjuvant and emulsifying it. The oil adjuvant formula (paraffin wax) oil: lanolin = 9:1). The immune effect of this vaccine is good, but there are the following deficiencies and problems: [0003] 1. The stability of the vaccine is poor and the stratification is fast. After storage, the emulsion seedlings will soon be divided into milky white and light red two layers. A small amount of oil layer can be folded on the emulsion surface. The appearance and physical properties are not good, and sometimes occur during the shelf life. Demulsification affects the quality of the vaccine. The main reason is ...

Claims

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Application Information

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IPC IPC(8): A61K39/125
Inventor 叶向阳潘雪珠张婉华潘饶霖许平曹伟明朱永军严仲烈唐骐骏
Owner 上海佳牧生物制品有限公司
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