Warm poultice

A technology of warming sensation and reducing agent, which is applied in the directions of anti-inflammatory agents, non-central analgesics, medical preparations with inactive ingredients, etc. And other issues

Inactive Publication Date: 2006-01-04
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the topical skin preparation containing L-menthol still has the problem of residual irritation caused by capsaicin. In addition, although the warming effect of capsaicin is relatively improved when combined with the cooling effect of L-menthol, but has a tendency to increase residual irritation
Therefore, a warm-sensing compress that sufficiently reduces the residual irritation has not been obtained.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] 55.55% of purified water, 3% of gelatin, 3% of polyacrylic acid, 3% of partially neutralized polyacrylic acid, 2% of polyvinyl alcohol, 1% of synthetic aluminum silicate, 0.3% of magnesium aluminosilicate, polyoxyethylene monohard Fatty acid ester 0.5%, disodium edetate 0.3%, methyl paraben 0.2%, glycerin 20%, polyethylene glycol 10%, L-menthol 1.0% and 10% capsicum extract 0.15% Stirring was performed until uniform dispersion and dissolution were carried out to prepare a coating liquid as the adhesive layer 1 . The compounding quantity of the capsaicin in the coating liquid was 0.015%. In addition, Macrogol 400 having a molecular weight of 400 was used as polyethylene glycol.

[0085] Then, spread the coating solution on the support body 2 to make it 1000g / m 2 , Paste the film. Then, cut it into 10cm×14cm to make a sheet-shaped warming compress.

[0086] In addition, the composition of the support body 2 used in Example 1 is a polyester non-woven fabric (weight per...

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Abstract

Warm poultice (10) comprising support (2) and, disposed on at least one major surface of the support (2), pressure sensitive adhesive layer (1), the pressure sensitive adhesive layer (1) comprising a warm feeling imparting substance, L-menthol and, as a residual stimulation reducing agent, polyethylene glycol.

Description

technical field [0001] The invention relates to a warm-sensing compress having a support body and an adhesive layer. technical background [0002] In the past, as a drug for imparting a warming sensation in the adhesive of a patch, for example, as described in JP-A-2000-143507, JP-A-6-256183, and JP-A-10-298065, capsaicin was used It represents the warmth imparting substance. Such a warming sensation-imparting substance must be compounded in a relatively large amount in the adhesive layer of the patch in order to maintain the warming sensation when the patch is used. However, when such a large amount of the warming sensation imparting substance is incorporated in the adhesive layer, skin irritation remains even after the patch is peeled off, that is, there is a problem of residual irritation. [0003] Especially, the residual irritation of capsaicin is strong, and the water-containing patch containing capsaicin is used in the occasion of bathing after the skin, and its res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61K31/165A61K9/70A61K47/10A61K47/34A61P43/00
CPCA61K31/165A61K31/045A61K47/10A61K9/7061A61P29/00A61P43/00A61K9/70A61K47/34
Inventor 牟田一则日溪智行
Owner HISAMITSU PHARM CO INC
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