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Novel drug administration route of semen armeniacae amarum injection, its preparation process and new indications

A method of administration and injection technology, which is applied in the field of traditional Chinese medicine preparation Kumu injection, and can solve the problems of injection induration, slow speed, and small dosage

Inactive Publication Date: 2006-02-08
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in terms of actual clinical application, Kumu injection adopts the intramuscular injection method, which is absorbed through the tissue at a slower rate and with a smaller dose, which not only increases the pain of the patient, but also causes local induration of the injection, even swelling and pain, and secondary infection. , frequent injections can easily lead to "gluteal muscle contracture"
This medication method obviously limits its clinical application
Therefore, in response to this problem, we have developed an intravenous route of administration, which overcomes the shortcomings of slow absorption and long onset time

Method used

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  • Novel drug administration route of semen armeniacae amarum injection, its preparation process and new indications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation method of injection of the present invention is as follows:

[0046] prescription:

[0047] Bitterwood 500g

[0048] F-68 3~4g

[0049] Sodium chloride 4g

[0050] Makes 1000ml

[0051] Preparation:

[0052] Take bitter wood, crush it into coarse powder, heat and reflux extraction with 8 times the amount of 80% to 85% ethanol for two times, combine the extracts, recover the ethanol, concentrate into a thick paste, add 13 times the amount of ethanol to dissolve, filter , combine the filtrate, adjust the pH value to about 9 with sodium hydroxide solution, let it stand, filter, recover ethanol from the filtrate, concentrate it into a thick paste, extract it with 2% hydrochloric acid solution until the extract has no alkaloid reaction, and combine the extraction solution, adjust the pH value to 5-6 with sodium hydroxide solution, let it stand, filter, concentrate the filtrate into a thick paste, extract with ethanol in stages until the extract has no ob...

Embodiment 2

[0054] The preparation method of aseptic powder of the present invention is as follows:

[0055] prescription:

[0056] Bitterwood 2500g

[0057] F-68 15~20g

[0058] Sodium chloride 4g

[0059] Made 1000 pieces

[0060] Preparation:

[0061] Take bitter wood, crush it into coarse powder, heat and reflux extraction with 8 times the amount of 80% to 85% ethanol for two times, combine the extracts, recover the ethanol, concentrate into a thick paste, add 13 times the amount of ethanol to dissolve, filter , combine the filtrate, adjust the pH value to about 9 with sodium hydroxide solution, let it stand, filter, recover ethanol from the filtrate, concentrate it into a thick paste, extract it with 2% hydrochloric acid solution until the extract has no alkaloid reaction, and combine the extraction solution, adjust the pH value to 5-6 with sodium hydroxide solution, let it stand, filter, concentrate the filtrate into a thick paste, extract with ethanol in stages until the extra...

Embodiment 3

[0063] The preparation method of freeze-dried powder of the present invention is as follows:

[0064] prescription:

[0065] Bitterwood 2500g

[0066] F-68 15~20g

[0067] Sodium chloride 4g

[0068] Makes 1000 bottles

[0069] Preparation:

[0070] Take bitter wood, crush it into coarse powder, heat and reflux extraction with 8 times the amount of 80% to 85% ethanol for two times, combine the extracts, recover the ethanol, concentrate into a thick paste, add 13 times the amount of ethanol to dissolve, filter , combine the filtrate, adjust the pH value to about 9 with sodium hydroxide solution, let it stand, filter, recover ethanol from the filtrate, concentrate it into a thick paste, extract it with 2% hydrochloric acid solution until the extract has no alkaloid reaction, and combine the extraction solution, adjust the pH value to 5-6 with sodium hydroxide solution, let it stand, filter, concentrate the filtrate into a thick paste, extract with ethanol in stages until th...

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Abstract

The invention relates to a traditional Chinese medicinal injection for treating common cold, upper respiratory tract infection, acute tonsillitis, pneumonia, acute bronchitis and trauma infection, its preparing process, new route of administration and new indications. The injection is prepared from Kumu as raw material, and can be made into the forms of concentrated solution, freeze-dried powder injection, germ-free powdery 5% glucose injection, and 0.9% sodium chloride injection.

Description

Technical field: [0001] The invention relates to a new administration route, a preparation process and a new indication of the traditional Chinese medicine preparation bitter wood injection. technical background: [0002] Bitter wood injection is extracted and refined from the dry roots and stems of bitter wood, a plant of bitter wood, through scientific methods according to folk prescriptions. Anti-inflammatory and good anti-inflammatory, analgesic effect, widely used in clinical treatment of colds, upper respiratory tract infections, acute tonsillitis, enteritis, bacillary dysentery and other diseases have good results. It was developed in 1971 and approved to be put into production. It has been clinically used in many hospitals to treat infectious febrile diseases, and the total effective rate is 91%. Due to the good curative effect, stable quality and few side effects of this product, the production and sales have increased year by year for more than 20 years, and the m...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/08A61K9/14A61K9/19A61P11/00A61P17/02A61P27/02A61P13/10A61P13/02A61P13/12
Inventor 刘露
Owner FUKANGREN BIO PHARMA
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