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Hypericum perforatum L. total flavone extracts, its preparation and application

A technology of Hypericum perforatum and total flavonoids, applied in sugar derivatives, drug combinations, drug delivery, etc., can solve problems such as liver protection, treatment of hepatitis B and treatment of heart and brain ischemic diseases, and achieve the goal of treating heart and brain Ischemic disease, treatment of hepatitis B, effect of reliable curative effect

Inactive Publication Date: 2006-07-19
周亚球 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The traditional Chinese medicine Hypericum perforatum and its preparations are clinically used to treat mild and moderate depression, but there are no reports on liver protection, hepatitis B treatment and heart and brain ischemic diseases.

Method used

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  • Hypericum perforatum L. total flavone extracts, its preparation and application
  • Hypericum perforatum L. total flavone extracts, its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083]Take 1 kg of Hypericum perforatum crude drug crude powder, add 10 times the amount of 70% ethanol and heat and reflux for extraction for 2 hours, extract 3 times in total, combine the extracts, let cool, filter, recover ethanol under reduced pressure until there is no alcohol, and concentrate to 60°C When the relative density is 1.13; add boiling water equivalent to 6 times the amount of the crude drug and stir to dissolve, filter, add the filtrate to the mixed column of polyamide and macroporous adsorption resin, wash 10 column volumes with water, and then use 20% Elute 2 column volumes with ethanol aqueous solution, and 4 column volumes with 50% ethanol aqueous solution, collect 50% ethanol aqueous solution in sections, the eluent per 1 column volume is 1 part, collect the 2nd and the 3rd wash Remove the liquid, concentrate under reduced pressure at a temperature lower than 60°C, and dry in a vacuum to obtain an extract. Take the extract and add 10 times the amount of m...

Embodiment 2

[0086] Take 1 kg of Hypericum perforatum crude drug crude powder, add 8 times the amount of 80% ethanol, heat and reflux for extraction for 2 hours, extract 3 times in total, combine the extracts, let cool, filter, recover ethanol under reduced pressure until it is free of alcohol, and concentrate to 60°C When the relative density is 1.15; add boiling water equivalent to 4 times the amount of the crude drug and stir to dissolve, filter, add the filtrate to the polyamide column that has been treated, wash 10 column volumes with water, and wash with 20% ethanol aqueous solution Elute 2 column volumes, elute 4 column volumes with 50% ethanol aqueous solution, collect 50% ethanol aqueous solution in sections, every 1 column volume of eluent is 1 part, collect the 2nd and 3rd eluate , concentrated under reduced pressure at a temperature lower than 60°C, and dried in a vacuum to obtain an extract. Take the extract and add 10 times the amount of methanol, heat and reflux in a water ba...

Embodiment 3

[0089] Take 1 kg of Hypericum perforatum crude drug crude powder, add 10 times the amount of 90% ethanol to heat and reflux for extraction for 2 hours, extract 3 times in total, combine the extracts, let cool, filter, recover the ethanol under reduced pressure until there is no alcohol, and concentrate to 60°C Extraction with a relative density of 1.16; add boiling water equivalent to 6 times the amount of the crude drug and stir to dissolve, filter, add the filtrate to the treated polyamide column, wash 10 column volumes with water, and elute with 15% methanol 3 column volumes, 40% methanol aqueous solution elutes 4 column volumes, collects 40% methanol aqueous solution in sections, every 1 column volume of eluent is 1 part, collects the 2nd and 3rd part of eluent, at low Concentrate under reduced pressure at 60°C and dry in vacuum to obtain the extract. Take the extract and add 10 times the amount of ethanol, heat and reflux in a water bath for extraction for 2 hours, then he...

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Abstract

Disclosed is a Hypericum perforatum flavones extract, its preparation and use. the content of the flavones in the extract is 80-95%, the flavone-containing ingredients include birutan 5.0-50.0%, hyperoside 6.0-70.0%, isoquercitrin 3.0-10.0%, quercetin-3-O-alpha-L-arabinoside 0.5-5.0%, quercetin 0.5-5.0%, meletin 0.1-1.0%, and other balancing flavones components.

Description

Technical field: [0001] The invention relates to a total flavonoid extract of Hypericum perforatum, a preparation method of the extract, a traditional Chinese medicine preparation, and an application thereof in medicines for protecting the liver, treating hepatitis B, and treating heart and brain ischemia. Background technique: [0002] Hypericum perforatum (Hypericum perforatum) is the dry aerial part of Hypericum perforatum L., a plant of the genus Hypericum in the genus Hypericum perforatum. Functions and indications are: soothing the liver and relieving stagnation, clearing heat and promoting dampness, reducing swelling and alleviating pain. It is used for poor emotions, depression of qi stagnation, swelling and pain of joints, and dysuria. [0003] At present, the research methods of Hypericum perforatum extract include the invention patent application "Preparation method of Hypericum perforatum extract" with application number 02115540.2, and the "Preparation method o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07H17/04A61K31/352A61K9/20A61K9/48A61K9/14A61K9/08A61P1/16A61P31/12A61P9/10
Inventor 王先荣周亚球柯仲成
Owner 周亚球
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