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Ginkgolide emulsion for injection

A technology for ginkgolide and injection, which is applied in the field of ginkgolide injection emulsion, can solve the problems of large irritation of organic solvents, and achieve the effects of improving safety and effectiveness, increasing orientation, and reducing dosage

Inactive Publication Date: 2006-08-09
欧苏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, organic solvents are highly irritating, and safety is an issue to be solved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Dissolve 2.0 g of ginkgolide (mixture) and 22.5 g of glycerin in water for injection, and dissolve 12.0 g of refined soybean lecithin in refined soybean oil, respectively heat to 50°C, mix well, and first emulsify fractionally in a tissue masher , and then emulsified by a high-speed homogenizer to meet the particle size of the preparation. Add water for injection to 1000ml, cool, and fill to obtain ginkgolide injection emulsion. This process is a 1000ml prescription, and the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0050] Dissolve 5.0g of ginkgolide and 25.0g of sorbitol in water for injection, dissolve 10g of refined lecithin in refined corn oil, heat to 45°C respectively, mix well, first emulsify fractionally in a tissue masher, and then The homogenizer emulsifies to meet the particle size of the preparation. Add water for injection to 1000ml.

Embodiment 3

[0052] Dissolve 10.0g of ginkgo extract and 55.5g of xylitol in water for injection, dissolve 15.0g of refined lecithin in refined sesame oil, heat to 60°C respectively, mix well, first emulsify fractionally in a tissue masher, and then The high-speed homogenizer emulsifies to meet the particle size of the preparation. Add water for injection to 1000ml.

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PUM

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Abstract

The present invention discloses a bilobalide (mixture or ginkgo extract) emulsion for injection, in particular, it relates to a bilobalide (including single bilobalide A, B and C, etc.) injection emulsion for curing angiocardiopathy and cerebrovascular disease. It is made up by using bilobalide and medicinal auxiliary material according to a certain ratio through the processes of dissolving, heating, uniformly mixing, emulsifying, cooling and filling to obtain the invented product.

Description

technical field [0001] The present invention relates to a kind of ginkgolide (mixture or ginkgo extract) emulsion for injection, especially relate to a kind of ginkgolide (comprising single ginkgolide A, B, C etc.) Injectable emulsion. Background technique [0002] Ginkgo biloba extract has been extensively studied at home and abroad. The pharmacological research is in-depth and the mechanism is clear. The main active ingredient is ginkgolide, including ginkgolide A, ginkgolide B, ginkgolide C, etc. and bilobalide. PAF is an endogenous phospholipid secreted by platelets and various inflammatory tissues. It is closely related to the occurrence and development of many diseases. Ginkgolide is the most valuable PAF antagonist in clinical application so far. The development of this product can provide Make greater contributions to the health of our people and our medicine to the world. Among them, capsules, tablets and injections are widely used clinically to treat brain and pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K31/365A61K9/107A61P9/10A61P25/00
Inventor 欧苏尹爱梅
Owner 欧苏
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