Cross-linked pachyman, its prepn. and uses

A technology of cross-linking Poria cocos polysaccharide and Poria cocos polysaccharide, which is applied in the direction of medical formula, medical preparations containing active ingredients, organic active ingredients, etc., and can solve the problems of inconspicuous pharmacological effects, etc.

Inactive Publication Date: 2006-09-20
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poria cocos is a kind of traditional Chinese medicine, many scholars have conducted extensive research on it, but a large number of experiments have proved that the pharmacological effect of Poria cocos polysaccharide as an anti-tumor drug is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Preparation of Crosslinked Pachyranan 1

[0019] 1. Preparation of Poria cocos polysaccharide

[0020] Grind commercially available fresh Poria cocos sclerotium into powder, pass through a 60-mesh sieve, take 600 g and dissolve in 0.5 wt% NaOH solution (the mass ratio of Poria cocos powder to NaOH solution is 1:100), and the temperature is controlled at 0°C to 5°C. ℃, stirred until thick, left overnight, filtered with suction to obtain the filtrate, then neutralized the filtrate with 10% acetic acid, placed overnight at 0°C to 5°C, filtered with suction to obtain a white precipitate, washed the precipitate with water, ethanol, and acetone ethyl ether in sequence, at 20°C Dried at ~50°C to obtain pachyphyllin.

[0021] 2. Preparation of Cross-linked Pachyranan 1

[0022] Add 2 times of the quality of pachyrhynch in 30g of pachyrhiza, after stirring evenly, add 5% aqueous sodium hydroxide solution to make the pH of the whole system be 9, stir mechanically, ad...

Embodiment 2

[0023] Embodiment two: the preparation of cross-linked pachymansin 2

[0024] Grind commercially available fresh Poria cocos sclerotium into powder, pass through a 60-mesh sieve, take 60g and dissolve in 2wt% sodium hydroxide solution (the mass ratio of Poria cocos powder to NaOH solution is 1: 100), and the temperature is controlled at 0° C. 5°C, stirred until thick, left overnight, suction filtered to obtain the filtrate, adjusted the pH value to 10, mechanically stirred, when the reaction temperature reached 35°C, added 0.03 g of epichlorohydrin, cross-linked for 8 hours, and then used 1mol / 1 L of dilute sulfuric acid neutralized the reaction product to a pH value of 5-6, filtered, washed, and freeze-dried to obtain cross-linked pachyan 2 with a sedimentation volume of 6.9 mL.

Embodiment 3

[0025] Embodiment 3: Preparation of cross-linked pachymansin 3

[0026] Add 5 times the quality of pachyrhizan in 30g pachyrhizan (commercially available), after stirring evenly, add 5% sodium hydroxide aqueous solution, make the pH of the whole system be 11, stir mechanically, add pachyrhin when the reaction temperature reaches 45°C 0.1% epichlorohydrin by mass, cross-linking reaction for 10 hours, and then neutralize the reaction product with 1mol / L dilute sulfuric acid to a pH value of 5-6, filter, wash, freeze-dry to obtain a sedimentation volume of 6.7mL Cross-linked pachymansin3.

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Abstract

This invention relates to cross-linking pachyman, its preparation method and application. The cross-linking pachyman is prepared as follows: pachyman is mixed with two to five-fold mass of water or alcohol to form a mixture and the pH value is adjusted to 9~11. Epichlorohydrin with a mass 0.1~0.5% of pachyman is added and the cross-linking reaction is kept at 35~45 deg. C for 6~10 hours. The mixture is then neutralized, filtered, washed and lyophilized to obtain cross-linking pachyman. The cross-linking pachyman in this invention has good fluidity, strong water-absorption, high bulk density and dilatability and can be used as efficient disintegrating reagent. The cross-linking pachyman is homogeneously dispersed into powders during disintegration so that the disintegrating ability of the troches is enhanced and the disintegrating efficiency is promoted.

Description

Technical field: [0001] The invention relates to cross-linked pachyrhythmic polysaccharide and its preparation method and application. Background technique: [0002] Pharmaceutical excipients are the material basis for the existence of pharmaceutical preparations and the necessary materials for the production of pharmaceutical preparations. Therefore, all countries in the world attach great importance to the development of new pharmaceutical excipients. [0003] Tablets are the most widely used oral solid preparations. To improve the quality of tablets, choosing good excipients is the key. Fillers and disintegrants are the most important excipients in ordinary tablets, and the selection of these excipients directly affects the internal quality of the tablet and the curative effect of the drug. At present, the commonly used auxiliary materials mainly include starch, cellulose, alginic acid, clay, PVP, gum and so on. [0004] With the development of pharmaceutical preparatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/738
Inventor 胡先明张郦肖玉玲王丽娟梁淑彩邱国福
Owner WUHAN UNIV
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