Cross-linked pachyman, its prepn. and uses

Abstract

This invention relates to cross-linking pachyman, its preparation method and application. The cross-linking pachyman is prepared as follows: pachyman is mixed with two to five-fold mass of water or alcohol to form a mixture and the pH value is adjusted to 9~11. Epichlorohydrin with a mass 0.1~0.5% of pachyman is added and the cross-linking reaction is kept at 35~45 deg. C for 6~10 hours. The mixture is then neutralized, filtered, washed and lyophilized to obtain cross-linking pachyman. The cross-linking pachyman in this invention has good fluidity, strong water-absorption, high bulk density and dilatability and can be used as efficient disintegrating reagent. The cross-linking pachyman is homogeneously dispersed into powders during disintegration so that the disintegrating ability of the troches is enhanced and the disintegrating efficiency is promoted.

Description

Technical field:

[0001] The invention relates to cross-linked pachyrhythmic polysaccharide and its preparation method and application. Background technique:

[0002] Pharmaceutical excipients are the material basis for the existence of pharmaceutical preparations and the necessary materials for the production of pharmaceutical preparations. Therefore, all countries in the world attach great importance to the development of new pharmaceutical excipients.

[0003] Tablets are the most widely used oral solid preparations. To improve the quality of tablets, choosing good excipients is the key. Fillers and disintegrants are the most important excipients in ordinary tablets, and the selection of these excipients directly affects the internal quality of the tablet and the curative effect of the drug. At present, the commonly used auxiliary materials mainly include starch, cellulose, alginic acid, clay, PVP, gum and so on.

[0004] With the development of pharmaceutical preparatio...