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Ginsenoside F1 medicinal uses

A technology of ginsenosides and medicines, applied in the field of medicine, can solve problems such as controversial curative effect, and achieve the effect of less side effects, prevention or treatment of dementia syndrome

Inactive Publication Date: 2006-10-04
海口绿科南药研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are some chemical drugs for senile dementia on the market, their efficacy is still controversial, so the development of drugs for the treatment of dementia syndrome will have important clinical significance

Method used

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  • Ginsenoside F1 medicinal uses

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0063] Preparation Example 1 Ginsenoside F 1 preparation of

[0064] 500mg ginsenoside Re and 150mg naringinase were dissolved in 50ml of phosphoric acid-citric acid buffer (pH 4.5, ionic strength 0.01M, containing 10% ethanol), hydrolyzed in a water bath at 40°C for 7 days; the reaction solution was centrifuged Collect the precipitate; wash the precipitate with 10ml of water, wash 3 times (10ml×3), combine the washing liquid with the mother liquor, concentrate to 50ml for reuse; wash the precipitate with 10ml ethanol, wash 5 times (10ml×5), combine the ethanol solution, Evaporate to dryness and collect the residue to obtain ginsenoside F 1 301mg. Determination of Ginsenoside F by HPLC 1 The content is 63%.

preparation example 2

[0065] Preparation Example 2 Ginsenoside F 1 preparation of

[0066] 500mg Ginsenoside Rg 1 , 150mg of naringinase was dissolved in 50ml of glycine-HCl buffer (pH 4.5, ionic strength 0.01M, containing 10% dimethyl sulfoxide), and hydrolyzed in a water bath at 40°C for 7 days; the reaction solution was centrifuged to collect the precipitate ; Wash the precipitate with 10ml of water, wash 3 times (10ml × 3), combine the lotion with the mother liquor, concentrate to 50ml for reuse; wash the precipitate with 10ml of ethanol, wash 5 times (10ml × 5), combine the ethanol solution, evaporate to dryness , collect the residue to get ginsenoside F 1 325mg. Determination of Ginsenoside F by HPLC 1 The content is 84%.

preparation example 3

[0067] Preparation Example 3 Ginsenoside F 1 preparation of

[0068] 500mg Ginsenosides Re and Rg 1 Mixture, 150mg of naringinase was dissolved in 50ml of acetic acid-sodium acetate buffer solution (pH 4.5, ionic strength of 0.01M, containing 10% formamide), and hydrolyzed in a water bath at 40°C for 7 days; the reaction solution was collected by centrifugation Precipitate; wash precipitate with 10ml water, wash 3 times (10ml×3), wash liquid and mother liquor merge, concentrate to 50ml for reuse; wash precipitate with 10ml ethanol, wash 5 times (10ml×5), combine ethanol liquid, distill Dry and collect the residue to get ginsenoside F 1 310mg. Determination of Ginsenoside F by HPLC 1 The content is 69%.

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Abstract

Disclosed is the use of Ginsenoside F1 in preparing medicament for the treatment of vascular dementia and Alzheimer's disease.

Description

technical field [0001] The present invention relates to the technical field of medicine, specifically ginsenoside F 1 (ginsenoside F 1 ) for medicinal purposes. [0002] [0003] Ginsenoside F 1 [0004] Molecular formula: C 36 h 62 o 9 Molecular weight: 638.87 Background technique [0005] Ginseng (Panax ginseng C.A.Mey.) is the root of the Araliaceae plant ginseng, which is distributed in the deep mountains of Heilongjiang, Jilin, Liaoning and northern Hebei. As a commonly used Chinese herbal medicine, it was first recorded in "Shen Nong's Materia Medica" in the Han Dynasty, and was listed as top grade. Ginseng is warm in nature, sweet and slightly bitter in taste, and has the functions of invigorating vital energy, solidifying and promoting body fluid, improving intelligence and calming the nerves. It is used to treat exhaustion due to fatigue, lack of food, fatigue, nausea and vomiting, slippery stool, cough due to deficiency, shortness of breath, spontaneo...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P25/28
Inventor 吴巍邵萌翟大伟滕厚雷
Owner 海口绿科南药研究开发有限公司
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