Schweineseuche O-shaped synthetic peptide vaccine and preparation thereof

Abstract

An O-type synthetase vaccine for the mouth-and-foot disease of pig is a polypeptide containing the amino acid sequence shown by SEQ ID No.1. Its preparing process includes such steps as activating amino acid, synthesizing reaction, acetylating, cyclizing, desalting, purifying, and mixing the resultant synthetase antigen with oily emulsion.

Description

technical field [0001] The invention relates to a foot-and-mouth disease vaccine, in particular to a swine foot-and-mouth disease O-type synthetic peptide vaccine, and a preparation method thereof. Background technique [0002] Foot-and-mouth disease (FMD), caused by foot-and-mouth disease virus (FMDV), is one of the most serious livestock infectious diseases in the world. Immunization is the main means of controlling the disease at present. At present, the traditional inactivated vaccine is still the leading method for the prevention and treatment of foot-and-mouth disease at home and abroad, but it is easy to cause side effects such as allergies, and it will also cause biosafety problems. In addition, the use of inactivated vaccines often interferes with the normal diagnosis of foot-and-mouth disease. Therefore, a large number of researches on new vaccines have been carried out at home and abroad. Since the 1970s, there have been reports of genetically engineered subunit ...

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Problems solved by technology

However, due to the limited amount of gene expression products and the inability to realize t