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Bilobalide B emulsion for injection

A technology for ginkgolide and injection, which is applied in the field of ginkgolide B emulsion, which can solve the problems of large irritation of organic solvents, improve safety and effectiveness, improve curative effect, increase orientation and harmonize cancer cells Effect

Inactive Publication Date: 2006-11-08
欧苏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, organic solvents are highly irritating, and safety is an issue to be solved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Dissolve 22.5g of glycerin in water for injection, 2.0g of ginkgolide B and 12.0g of refined soybean lecithin in refined soybean oil, respectively heat to 50°C, mix well, first emulsify fractionally in a tissue masher, and then Emulsified by a high-speed homogenizer to meet the particle size of the preparation. Add water for injection to 1000ml, cool, and fill to obtain ginkgolide B injection emulsion. This process is a 1000ml prescription, and the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0038] Dissolve 25.0 g of sorbitol in water for injection, 5.0 g of ginkgolide B and 10 g of refined lecithin in refined corn oil, respectively heat to 45°C, mix well, first fractionally emulsify in a tissue masher, and then The high-speed homogenizer emulsifies to meet the particle size of the preparation. Add water for injection to 1000ml.

Embodiment 3

[0040] Dissolve 55.5g of xylitol in water for injection, 10.0g of ginkgolide B and 15.0g of refined lecithin in refined sesame oil, heat to 60°C respectively, mix well, first emulsify fractionally in a tissue masher, and then Emulsified by a high-speed homogenizer to meet the particle size of the preparation. Add water for injection to 1000ml.

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PUM

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Abstract

The present invention discloses a kind of bilobalide B emulsion for injection to treat cardiac and cerebral vascular diseases. The bilobalide B emulsion for injection is prepared with bilobalide B and medicinal supplementary material in certain ratio, and through dissolving, heating, mixing, emulsifying, cooling, filling and other technological steps. The bilobalide B emulsion for injection has high structural integrity and bioactivity of bilobalide B, high stability, high safety a high effectiveness. It is used for treating cardiac and cerebral vascular diseases, and can treat cardiac and cerebral vascular diseases in high effect and provide the patient with energy.

Description

technical field [0001] The invention relates to a ginkgolide B emulsion for injection, in particular to a ginkgolide B injection emulsion for cardiovascular and cerebrovascular diseases. Background technique [0002] Ginkgo biloba extract has been extensively studied at home and abroad. The pharmacological research is in-depth and the mechanism is clear. The main active ingredient is ginkgolide, including ginkgolide A, ginkgolide B, ginkgolide C, etc. and bilobalide. And the most important is ginkgolide B. PAF is an endogenous phospholipid secreted by platelets and various inflammatory tissues. It is closely related to the occurrence and development of many diseases. Ginkgolide B is the most valuable PAF antagonist in clinical application so far. The development of this product can Make greater contributions to the health of our people and our medicine to the world. Among them, capsules, tablets and injections are widely used clinically to treat brain and peripheral blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/107A61P9/00A61P9/10
Inventor 欧苏尹爱梅
Owner 欧苏
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