Penciclovir gel and its preparing method

A technology of penciclovir and vir gel, which is applied in the field of pharmaceutical preparations containing penciclovir and its preparation, and can solve the problems of greasy feeling and inconvenient medication for patients

Inactive Publication Date: 2006-11-08
陈益智
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Penciclovir is a broad-spectrum anti-herpes virus drug, which has a strong inhibitory effect on chickenpox and herpes zoster. At present, ...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Penciclovir 100g

[0011] Carbomer 100g

[0012] 0.1mol / L sodium hydroxide 40g

[0013] Add purified water to 10000g

[0014] Made 1000 pieces

[0015] Add the prescribed amount of penciclovir to 0.1mol / L sodium hydroxide, heat to 50°C, stir, dissolve completely and keep warm to obtain a penciclovir solution, then mix it with carbomer evenly, wait for it to swell, and then Stir well, add purified water to the full amount. Vacuumize, remove air bubbles, fill quantitatively, and seal to obtain the finished product of penciclovir gel.

Embodiment 2

[0017] Penciclovir 100g

[0018] Carbomer 100g

[0019] Triethanolamine 135g

[0020] Add purified water to 10000g

[0021] Made 1000 pieces

[0022] Add the prescribed amount of penciclovir into the triethanolamine solution, heat to 50°C, stir, dissolve completely and keep warm to obtain the penciclovir solution, then mix it with carbomer evenly, wait for it to swell, then stir evenly, Add purified water to full volume. Vacuumize, remove air bubbles, fill quantitatively, and seal to obtain the finished product of penciclovir gel.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention provides a kind of new penciclovir preparation form, penciclovir gel. The penciclovir gel consists of penciclovir, matrix, pH regulator and water. The preparation process of the penciclovir gel includes dissolving penciclovir and pH regulator in water through heating and stirring to obtain penciclovir solution; mixing with the hydrophilic matrix; adding pure water to required amount; and vacuumizing to eliminate bubble, filling and sealing to obtain penciclovir gel product. Compared with available cream, the penciclovir gel is comfortable and has no greasy feeling.

Description

technical field [0001] The invention relates to a gel preparation, in particular to a pharmaceutical preparation containing penciclovir and a preparation method thereof. Background technique [0002] Penciclovir is a fully synthetic acyclovir antiviral drug. Penciclovir has inhibitory activity against HSV-1, HSV-2, VZV and E-B viruses, but is weak against cytomegalovirus (CMV). In cells infected with HSV-1, HSV-2 and VZV, penciclovir generates monophosphate under the action of viral thymidine kinase, which is further phosphorylated by cellular enzymes to generate the active metabolite penciclovir triphosphate Esters (PCV-TP). When PCV-TP in cells reaches a high concentration, it interacts with viral DNA polymerase, thereby inhibiting DNA synthesis. Penciclovir is a highly effective, safe and selective antiviral drug. [0003] Herpes virus infection is a common and frequently-occurring disease, and the recurrence rate of cold sores is relatively high. According to reports...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/522A61K9/00A61P31/12A61P31/22
Inventor 陈益智
Owner 陈益智
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap