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An in-vitro trichomonas vaginalis treating vaginal suppository and preparation method thereof

A technology for vaginal suppositories and trichomonas, which is applied in the delivery of suppositories, medical preparations containing active ingredients, anti-infectives, etc. It can solve the problems of mutagenesis, dyspnea, skin allergies, etc., and increase the curative effect and insecticidal rate The effect of high and reduced dosage

Inactive Publication Date: 2006-12-20
JIUJIANG UNIVERSITY +2
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  • Summary
  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0002] Since 1957, metronidazole has been the main drug of choice for anti-vaginal trichomonas. Although the therapeutic effect of this drug is good, the disadvantage is that trichomonas is drug-resistant. According to the US Center for Disease Control and Prevention in 1989, it was estimated that about 5% ~10% clinical drug resistance, in addition to drug-induced cell mutation, arrhythmia, dyspnea, skin allergies and other toxic side effects

Method used

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Examples

Experimental program
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Embodiment Construction

[0010] specific implementation plan

[0011] Embodiment of the invention

[0012] A vaginal suppository for treating trichomonas vaginalis in vitro, comprising 1 part of metronidazole, 2 parts of dihydroartemisinin, and 50 parts of cocoa butter. Its preparation method is as follows: take metronidazole and dihydroartemisinin and add about 17 parts of distilled water are dissolved to make an aqueous solution, then cocoa butter is added, and then mixed evenly to make 10 vaginal suppositories, which are pale yellow.

[0013] The content of each suppository is 0.002 mg / ml of metronidazole and 0.5 mg / ml of dihydroartemisinin.

[0014] Dihydroartemisinin is one of the derivatives of artemisinin. It has good absorption, wide distribution, rapid excretion and metabolism, high efficiency and low toxicity. Its oral bioavailability is more than 10 times that of artemisinin. Its antimalarial effect is 4-8 times that of artemisinin, and it is a broad-spectrum antiparasitic drug.

[0015]...

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PUM

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Abstract

The invention relates to a suppository for treating vaginal trichomonas in vitro and its preparation, wherein the main compositions of the suppository include metronidazole 0.8-1.2 parts, dihydro-artemisinin 1.6-2.4 parts, cocoa bean grease 40-60 parts.

Description

technical field [0001] The invention relates to a vaginal suppository for treating trichomonas vaginalis in vitro and a preparation method thereof. Background technique [0002] Since 1957, metronidazole has been the main drug of choice for anti-vaginal trichomonas. Although the therapeutic effect of this drug is good, the disadvantage is that trichomonas is drug-resistant. According to the US Center for Disease Control and Prevention in 1989, it was estimated that about 5% ~10% of clinical drug resistance, in addition to drug-induced cell mutation, arrhythmia, dyspnea, skin allergies and other toxic side effects. Contents of the invention [0003] The object of the present invention is to provide a vaginal suppository for treating trichomonas vaginalis in vitro and a preparation method thereof, which has the characteristics of low toxicity and high insecticidal rate. [0004] The technical scheme adopted to realize the above-mentioned purpose includes that the main compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61K9/02A61P15/02A61P33/02A61K31/4164
Inventor 高兴政朱进文汤自豪
Owner JIUJIANG UNIVERSITY
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