Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, preparation process and quality control method thereof

Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, its preparing process and quality control method, wherein Troxerutin and safflower flavones are employed in combination to obtain various dose forms of injections and oral administration preparations. The composite preparation is mainly used for treating cerebral hemorrhage, cerebral infarction, angina pectoris caused by coronary disease, vasculitis, arrhythmia, pulmonary heart disease, thrombotic phlebitis, capillary vessel hemorrhage, hyperlipemia, diabetic circumferential neuropathy, cervical vertebra diseases, fatty liver and edema.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, a preparation method and a quality control method thereof, and belongs to the technical field of medicines. technical background [0002] Cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, arrhythmia, cerebral thrombosis, stroke, etc. have become one of the important factors threatening human health. According to the survey, the incidence rate has been increasing in recent years, and there is a trend of younger people. The number of middle-aged and young patients is increasing. Cardiovascular and cerebrovascular diseases have become common and frequently-occurring diseases that endanger the health of our people. And current treatment medicine mainly concentrates on two aspects of pure Chinese medicine preparation and Western medicine, and Western medicine side effect is bigger; Although pure Chinese m...

AI Technical Summary

Problems solved by technology

And current treatment medicine mainly concentrates on two aspects of pure Chinese medicine preparation and Western medicine, and Western medicine side effect is bigger; Although pure Chinese medicine preparation has little toxic and side effects, their onset of effect is slower, affects therapeutic effect; In view of these situations, look for better, Compatibility is simple, the therapeutic effect is ideal, and the effective therapeutic drug with little side effect has become the problem that people urgently need to solve.

[0003] According to a large number of literatures, safflower, as a traditional Chinese medicine, has anti-thrombosis, inhibits platelet aggregation, anti-myocardial ischemia, can treat or prevent cardiovascular and cerebrovascular diseases, and has been widely favored by people in the pharmaceutical industry; Using medicinal materials as medicine is not only difficult to guarantee the quality, the dosage is large, but also the hygienic indicators are difficult to control; troxerutin can inhibit platelet aggregation, prevent thrombosis, and at the same time resist vascular damage caused by 5-hydroxytryptamine and bradykinin , increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability; mainly used for ischemic cerebrovascular diseases (such as cerebral thrombosis, cerebral embolism), thrombophlebitis, Diseases such as central retinitis, edema caused by increased vascular permeability; but because troxerutin has certain side effects, it is limited in clinical use; for this reason, the inventor adopts the effective part of total flavonoids of safflower to be directly used as medicine , combined with troxerutin to investigate its molding process and medicinal effect, and at the same time to study the optimal ratio range of safflower total flavonoids and troxerutin, so as to provide the possibility for the wider application of safflower preparations and troxerutin preparations , and at the same time provide patients with a safer and more effective pharmaceutical preparation with small fluctuations in curative effect and less toxic and side effects