Biologic device for regulation of gene expression and method therefor

US20070036770A1Inactive Publication Date: 2007-02-15CARDIAC PACEMAKERS INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
Publication Date
2007-02-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
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Description

CROSS-REFERENCE TO RELATED APPLICATION(S)

[0001] This application claims the benefit of U.S. Provisional Application No. 60 / 707,637, filed on Aug. 12, 2005, under 35 U.S.C. § 119(e), which is hereby incorporated by reference.FIELD OF THE INVENTION

[0002] This invention relates generally to gene therapy, for example, the use of genetically modified cells or recombinant gene therapy vectors, and particularly, but not by way of limitation, to method and apparatus for direct regulation of gene expression. BACKGROUND

[0003] The heart is the center of a person's circulatory system. It includes an electromechanical system performing two major pumping functions. The left portions of the heart draw oxygenated blood from the lungs and pump it to the organs of the body to provide the organs with their metabolic needs for oxygen. The right portions of the heart draw deoxygenated blood from the organs and pump it into the lungs where the blood gets oxygenated. The body's metabolic need for oxyge...

Examples

Embodiment Construction

[0024] In the following detailed description, reference is made to the accompanying drawings which form a part hereof, and in which is shown by way of illustration specific embodiments in which the invention may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention, and it is to be understood that the embodiments may be combined, or that other embodiments may be utilized and that structural, logical and electrical changes may be made without departing from the spirit and scope of the present invention. The following detailed description provides examples, and the scope of the present invention is defined by the appended claims and their equivalents.

[0025] It should be noted that references to “an”, “one”, or “various” embodiments in this disclosure are not necessarily to the same embodiment, and such references contemplate more than one embodiment.

General Overview

[0026] This document describes, among other...