Hair Care Product

Abstract

With an object of discovering a substance having a testosterone 5α-reductase inhibiting action, a hair papilla cell growth promoting action, a fibroblast growth factor-7 production promoting action, a vascular endothelial growth factor production promoting action or a bone morphogenetic protein-2 production promoting action, and of providing a hair care product having this substance blended therein, and a hair growth tonic, a testosterone 5α-reductase inhibitor, a hair papilla cell growth promoter, a fibroblast growth factor-7 production promoter, a vascular endothelial growth factor production promoter and a bone morphogenetic protein-2 production promoter each having this substance as an active ingredient thereof, a hair care product of the present invention is made to contain corosolic acid therein, and each of a hair growth tonic, a testosterone 5α-reductase inhibitor, a hair papilla cell growth promoter, a fibroblast growth factor-7 production promoter, a vascular endothelial growth factor production promoter and a bone morphogenetic protein-2 production promoter of the present invention is made to contain corosolic acid as an active ingredient thereof.

Description

TECHNICAL FIELD

[0001] The present invention relates to a hair growth tonic, a testosterone 5α-reductase inhibitor, a hair papilla cell growth promoter, a fibroblast growth factor-7 production promoter, a vascular endothelial growth factor production promoter, a bone morphogenetic protein-2 production promoter, and a hair care product.BACKGROUND ART

[0002] Many steroid hormones exhibit their action upon binding to a receptor in the molecular form secreted from the producing organ, but in the case of male hormones called androgens, for example testosterone enters into cells of the target organ and is reduced to 5α-dihydrotestosterone (5α-DHT) by testosterone 5α-reductase, and the 5α-DHT binds to a receptor and exhibits action as an androgen.

[0003] Androgens are important hormones, but if androgens act excessively, then various undesirable symptoms are brought about such as male pattern alopecia, hypertrichosis, seborrhea, acne (pimples etc.), benign prostatic hypertrophy, prostatic tumor,...

Examples

example 1

Blend Example 1

[0120]A hair tonic having the following composition was produced using an ordinary method.

Corosolic acid (Producing Example 1)0.1gPyridoxine hydrochloride0.1gResorcin0.01gD-pantothenyl alcohol0.1gDipotassium glycyrrhizinate0.1gSwertia extract0.2gL-menthol0.05g1,3-butylene glycol4.0gCarrot extract0.5gSophorae radix extract0.3gChamomile extract0.2gSalicylic acid0.2gSodium pyrrolidone carboxylate1.0gEthanol25.0gFragranceSuitable amountPurified waterRemainder (taking totalamount to be 100 g)

example 2

Blend Example 2

[0121]A hair lotion having the following composition was produced using an ordinary method.

Corosolic acid (Producing Example 1)0.01g1,3-butylene glycol6.0gEthanol8.0gPolyoxyethylene hydrogenated castor oil1.0g(40 E.O.)Polyoxysorbitan monostearate (20 E.O.)1.5gStearyl glycyrrhetinate0.2gEnmeiso extract0.5gOil-soluble licorice extract0.02gHinokitiol0.05gUrea3.0gNiacin0.1gDiphenhydramine hydrochloride0.1gTocopherol acetate0.05gMethyl paraoxybenzoate0.1gPhenoxyethanol0.3gL-menthol0.2gPurified waterRemainder (taking totalamount to be 100 g)

example 3

Blend Example 3

[0122]A hair growth tonic having the following composition was produced using an ordinary method.

Corosolic acid (Producing Example 1)0.5gHinokitiol0.1gGlycyrrhetic acid0.1gCepharanthin0.02gPolyoxyethylene hydrogenated castor oil1.5g(20 E.O.)1,3-butylene glycol3.0gEthanol60.0gTocopherol acetate0.1gCarrot extract0.1gCapsicum tincture2.0gGarlic extract0.5gPhotosensitizing dye 3010.005gPyridoxine hydrochloride0.05gD,L-menthol0.3gPurified waterRemainder (taking totalamount to be 100 g)

TECHNICAL FIELD

[0001] The present invention relates to a hair growth tonic, a testosterone 5α-reductase inhibitor, a hair papilla cell growth promoter, a fibroblast growth factor-7 production promoter, a vascular endothelial growth factor production promoter, a bone morphogenetic protein-2 production promoter, and a hair care product.BACKGROUND ART

[0002] Many steroid hormones exhibit their action upon binding to a receptor in the molecular form secreted from the producing organ, but in the case of male hormones called androgens, for example testosterone enters into cells of the target organ and is reduced to 5α-dihydrotestosterone (5α-DHT) by testosterone 5α-reductase, and the 5α-DHT binds to a receptor and exhibits action as an androgen.

[0003] Androgens are important hormones, but if androgens act excessively, then various undesirable symptoms are brought about such as male pattern alopecia, hypertrichosis, seborrhea, acne (pimples etc.), benign prostatic hypertrophy, prostatic tumor,...

Examples

example 1

Blend Example 1

[0120]A hair tonic having the following composition was produced using an ordinary method.

Corosolic acid (Producing Example 1)0.1gPyridoxine hydrochloride0.1gResorcin0.01gD-pantothenyl alcohol0.1gDipotassium glycyrrhizinate0.1gSwertia extract0.2gL-menthol0.05g1,3-butylene glycol4.0gCarrot extract0.5gSophorae radix extract0.3gChamomile extract0.2gSalicylic acid0.2gSodium pyrrolidone carboxylate1.0gEthanol25.0gFragranceSuitable amountPurified waterRemainder (taking totalamount to be 100 g)

example 2

Blend Example 2

[0121]A hair lotion having the following composition was produced using an ordinary method.

Corosolic acid (Producing Example 1)0.01g1,3-butylene glycol6.0gEthanol8.0gPolyoxyethylene hydrogenated castor oil1.0g(40 E.O.)Polyoxysorbitan monostearate (20 E.O.)1.5gStearyl glycyrrhetinate0.2gEnmeiso extract0.5gOil-soluble licorice extract0.02gHinokitiol0.05gUrea3.0gNiacin0.1gDiphenhydramine hydrochloride0.1gTocopherol acetate0.05gMethyl paraoxybenzoate0.1gPhenoxyethanol0.3gL-menthol0.2gPurified waterRemainder (taking totalamount to be 100 g)

example 3

Blend Example 3

[0122]A hair growth tonic having the following composition was produced using an ordinary method.

Corosolic acid (Producing Example 1)0.5gHinokitiol0.1gGlycyrrhetic acid0.1gCepharanthin0.02gPolyoxyethylene hydrogenated castor oil1.5g(20 E.O.)1,3-butylene glycol3.0gEthanol60.0gTocopherol acetate0.1gCarrot extract0.1gCapsicum tincture2.0gGarlic extract0.5gPhotosensitizing dye 3010.005gPyridoxine hydrochloride0.05gD,L-menthol0.3gPurified waterRemainder (taking totalamount to be 100 g)

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