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Detector and Method for Detection of H. Pylori

a detection method and technology for h. pylori, applied in the field of portable, handheld, point-of-care medical diagnostic devices, can solve the problems of inability to assess treatment efficacy, inability to use gastrointestinal endoscopy to obtain mucosal biopsies, inconvenient operation, etc., and achieves the effects of convenient operation, non-invasive, and convenient portability

Inactive Publication Date: 2012-09-20
RIGAS ANASTASIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]As a result the present invention provides a highly sensitive and specific ammonia sensing device for the detection of H. Pylori which is inexpensive, non-invasive, portable, point-of-care and easy to operate.
[0010]The present invention eliminates the need for serologic testing for antibodies to H. Pylori, for gastrointestinal endoscopy to obtain mucosal biopsies and culture for H. Pylori, for stool-testing for the detection of H. Pylori antigen and for the detection of H. Pylori using 13C-Urea Breath Test.

Problems solved by technology

Pylori is an inefficient diagnostic tool as it cannot be used to assess treatment efficacy and eradication of H.
Gastrointestinal endoscopy to obtain mucosal biopsies is an invasive and expensive method to detect the presence of H.
Pylori antigen is inefficient and cumbersome and has the lowest sensitivity and specificity of all available H.
13C-Urea Breath Test is expensive and requires breath samples to be transported to a central lab facility for testing.
Limitations of widespread use of 13C-UBT arise from the high cost of 13C-urea and of the instrument to detect 13CO2.

Method used

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  • Detector and Method for Detection of H. Pylori
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Embodiment Construction

[0022]A preferred embodiment will be described, but the embodiment is merely one example of how to practice the invention, and the invention is not limited to this embodiment.

[0023]FIG. 1 shows a breath-analyzer which consists of mouth piece, trap, emeraldine-base polyaniline (PANI-EB) sensor, N2 flow, and electronics. The electronics comprise an acquisition module, a memory / computation module, and a yes / no display, and a numerical display.

[0024]Technologies based on polymer thin films for electronic and chemical sensor applications are currently under development and are enabled by the availability of a special class of polymeric materials referred to as conjugated polymers—or conducting polymers. These conducting polymers are being investigated for chemical sensor applications, and initial work focuses on the use of the emeraldine forms of polyaniline (PANI), a schematic of which is shown in FIG. 2. Polyaniline is particularly useful as a chemical sensor for detection of ammonia v...

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PUM

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Abstract

An inexpensive, portable, hand held, point-of-care, non-invasive breath-analyzer for the detection of H. Pylori in adults and children by measuring ammonia in breath using a polyaniline-carbon nanotube sensor.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority on U.S. Provisional Application Ser. No. 61 / 452,391 filed Mar. 14, 2011, which is incorporated by reference herein. This application also incorporates by reference U.S. Ser. No. 61 / 379,963 filed Sep. 3, 2010, U.S. Ser. No. 13 / 226,082 filed Sep. 6, 2011, and U.S. Ser. No. 61 / 452,507 filed Mar. 14, 2011.FIELD OF THE INVENTION[0002]This invention relates to a portable, hand-held, point-of-care medical diagnostic device for the detection of Helicobacter Pylori (H. Pylori) with unlabeled urea and utilizing an ammonia specific and sensitive nanosensor constructed using a polyaniline (PANI)-carbon nanotube composite.BACKGROUND OF THE INVENTION[0003]H. Pylori, a well-known pathogen of the human digestive tract, colonizes the gastrointestinal mucosa at any age, most commonly in childhood. H. Pylori has been associated with significant morbidity and mortality being etiologically linked to peptic ulcer disease, bleed...

Claims

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Application Information

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IPC IPC(8): C12Q1/04C12M1/34
CPCG01N33/497G01N2800/06G01N33/84A61B5/082A61B5/097A61B5/4255
Inventor RIGAS, ANASTASIA
Owner RIGAS ANASTASIA